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New drug combo aims to tame painful muscle condition and cut steroid dependence

NCT ID NCT07286214

Recruiting now Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding sarilumab (a drug that calms inflammation) to a slow steroid taper can help people with early polymyalgia rheumatica achieve lasting remission. About 300 adults aged 50 and older will receive either sarilumab or a placebo, along with a 52-week prednisone reduction plan. The goal is to see if sarilumab allows more patients to stop steroids without symptoms returning.

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Conditions

The condition(s) this trial relates to.

polymyalgia rheumatica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYMYALGIA RHEUMATICA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Altoona Center for Clinical Research - Duncansville- Site Number : 8400018

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Clinical Research of West Florida - Phase I Unit- Site Number : 8400024

    RECRUITING

    Clearwater, Florida, 33765, United States

  • Denver Arthritis Clinic - Lowry- Site Number : 8400001

    RECRUITING

    Denver, Colorado, 80230, United States

  • Discovery Clinical Research - Plantation- Site Number : 8400091

    RECRUITING

    Plantation, Florida, 33324, United States

  • Florida Research Center- Site Number : 8400084

    RECRUITING

    Miami, Florida, 33174, United States

  • Innovia Research Center- Site Number : 8400029

    RECRUITING

    Miramar, Florida, 33027, United States

  • Inspire Santa Fe Medical Group- Site Number : 8400077

    RECRUITING

    Santa Fe, New Mexico, 87505, United States

  • Investigational Site Number : 1240003

    RECRUITING

    Sherbrooke, Quebec, J1G 2E8, Canada

  • Pennsylvania Regional Center for Arthritis and Osteoporosis Research- Site Number : 8400013

    RECRUITING

    Wyomissing, Pennsylvania, 19610, United States

  • TAD Clinical Research - Lufkin- Site Number : 8400069

    RECRUITING

    Lufkin, Texas, 75904, United States

  • Vantage Clinical Trials - Tampa- Site Number : 8400064

    RECRUITING

    Tampa, Florida, 33614, United States

  • Vitalia Medical Research - Margate- Site Number : 8400021

    RECRUITING

    Margate, Florida, 33063, United States

  • West Tennessee Research Institute- Site Number : 8400009

    RECRUITING

    Jackson, Tennessee, 38305, United States

  • Willow Rheumatology and Wellness- Site Number : 8400012

    RECRUITING

    Willowbrook, Illinois, 60527, United States

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