New drug combo aims to tame painful muscle condition and cut steroid dependence
NCT ID NCT07286214
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding sarilumab (a drug that calms inflammation) to a slow steroid taper can help people with early polymyalgia rheumatica achieve lasting remission. About 300 adults aged 50 and older will receive either sarilumab or a placebo, along with a 52-week prednisone reduction plan. The goal is to see if sarilumab allows more patients to stop steroids without symptoms returning.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Altoona Center for Clinical Research - Duncansville- Site Number : 8400018
RECRUITINGDuncansville, Pennsylvania, 16635, United States
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Clinical Research of West Florida - Phase I Unit- Site Number : 8400024
RECRUITINGClearwater, Florida, 33765, United States
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Denver Arthritis Clinic - Lowry- Site Number : 8400001
RECRUITINGDenver, Colorado, 80230, United States
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Discovery Clinical Research - Plantation- Site Number : 8400091
RECRUITINGPlantation, Florida, 33324, United States
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Florida Research Center- Site Number : 8400084
RECRUITINGMiami, Florida, 33174, United States
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Innovia Research Center- Site Number : 8400029
RECRUITINGMiramar, Florida, 33027, United States
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Inspire Santa Fe Medical Group- Site Number : 8400077
RECRUITINGSanta Fe, New Mexico, 87505, United States
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Investigational Site Number : 1240003
RECRUITINGSherbrooke, Quebec, J1G 2E8, Canada
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Pennsylvania Regional Center for Arthritis and Osteoporosis Research- Site Number : 8400013
RECRUITINGWyomissing, Pennsylvania, 19610, United States
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TAD Clinical Research - Lufkin- Site Number : 8400069
RECRUITINGLufkin, Texas, 75904, United States
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Vantage Clinical Trials - Tampa- Site Number : 8400064
RECRUITINGTampa, Florida, 33614, United States
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Vitalia Medical Research - Margate- Site Number : 8400021
RECRUITINGMargate, Florida, 33063, United States
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West Tennessee Research Institute- Site Number : 8400009
RECRUITINGJackson, Tennessee, 38305, United States
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Willow Rheumatology and Wellness- Site Number : 8400012
RECRUITINGWillowbrook, Illinois, 60527, United States