Could a different dosing schedule improve breast cancer treatment?
NCT ID NCT06926920
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a different dose and schedule of the drug sacituzumab govitecan (Trodelvy) in people with advanced triple-negative breast cancer that has not responded to prior treatment. The trial has two phases: phase 1 checks safety and the best dose, and phase 2 measures how well the drug shrinks tumors and delays cancer growth. About 100 adults with this type of breast cancer will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sacituzumab govitecan (Trodelvy)
- What this could lead to
- If successful, this could offer a more effective or better-tolerated dosing option for people with advanced triple-negative breast cancer.
- What could go wrong
- This is an early-phase trial (phase 1/2) with only 100 participants, so results may not apply broadly. The drug can cause side effects like nausea, fatigue, and low blood cell counts.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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John Flynn Private Hospital
RECRUITINGTugun, Queensland, 4224, Australia
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Los Angeles Cancer Network (LACN) - Good Sam
RECRUITINGLos Angeles, California, 90017, United States
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITINGSeoul, 03722, South Korea
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Siteman Cancer Center
RECRUITINGSt Louis, Missouri, 63110, United States
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St. Vincent's Hospital - Kinghorn Cancer Center
RECRUITINGDarlinghurst, New South Wales, 2010, Australia
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Sunshine Coast University Private Hospital
RECRUITINGBirtinya, Queensland, 4575, Australia
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Tennessee Oncology, PLLC
RECRUITINGNashville, Tennessee, 37203, United States
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Texas Oncology - DFW
RECRUITINGDallas, Texas, 75246, United States
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The University of Kansas Hospital
RECRUITINGWestwood, Kansas, 66205, United States
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
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West Cancer Centre
RECRUITINGGermantown, Tennessee, 38138, United States
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Winship Cancer Institute - Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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