Can a Low-Dose anesthetic cut opioid use after hysterectomy?
NCT ID NCT02543385
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether giving a low dose of S-ketamine during anesthesia can reduce the need for morphine and its side effects in women undergoing open abdominal hysterectomy for benign conditions. Half the participants receive S-ketamine, while the other half receive a placebo, and the study compares their morphine use over the first 24 hours after surgery. The goal is to see if this approach can make pain management safer and more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- S-ketamine (a low-dose anesthetic drug given intravenously during surgery)
- What this could lead to
- If effective, this could offer a way to reduce opioid use and related side effects after abdominal hysterectomy, potentially improving recovery.
- What could go wrong
- This is a small, early-stage trial, and results may not apply to all patients. S-ketamine can have side effects like nausea or dizziness, and its benefit over placebo is not yet proven.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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