New hope for kids with rare bleeding disorder: study tests rVWF treatment
NCT ID NCT02932618
First seen May 16, 2026 · Last updated May 16, 2026
Summary
This study tested a medicine called vonicog alfa (rVWF) to control bleeding in 47 children under 18 with severe von Willebrand disease, a genetic bleeding disorder. The treatment was given with or without another factor product (ADVATE) for 12-18 months. The goal was to see how well it stops bleeding episodes and if it is safe, but it is not a cure—children will still need ongoing management.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AKH - Medizinische Universität Wien
Vienna, 1090, Austria
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Azienda Ospedaliera Pediatrica Santobono Pausillipon
Naples, 80122, Italy
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Azienda Ospedaliera Universitaria Careggi
Florence, 50134, Italy
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Bleeding and Clotting Disorders Institute
Peoria, Illinois, 61615, United States
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CHU CAEN - Hôpital de la Côte de Nacre
Caen, 14033, France
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CHU de Nantes Site Hotel Dieu
Nantes, 44093, France
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Comprehensive Cancer Center of Wake Forest Unversity
Winston-Salem, North Carolina, 27157, United States
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Comprehensive Center for Bleeding Disorders
Milwaukee, Wisconsin, 53225, United States
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Ege University Medical Faculty
Izmir, 35100, Turkey (Türkiye)
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Erasmus Medisch Centrum
Rotterdam, 3015 CN, Netherlands
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FSBI of Science "Kirov Scientific and Research Institute of Hematology and Blood Transfusion of FMBA
Kirov, 610027, Russia
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Fakultni nemocnice Brno
Brno, 613 00, Czechia
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Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Groupe Hospitalier Pellegrin - Hôpital Pellegrin
Bordeaux, 33000, France
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Groupement Hospitalier Est- Hôpital Louis Pradel
Bron, 69677, France
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Groupement Hospitalier Sud - Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
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Hopital Cardiologique - CHU Lille
Lille, 59037, France
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Hospital General Universitario de Alicante
Alicante, 03010, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hôpital Morvan
Brest, Finistere, 29609, France
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Hôpital Necker - Enfants Malades
Paris, 75743, France
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Indiana Hemophilia and Thrombosis Center
Indianapolis, Indiana, 46260, United States
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Istanbul University Cerrahpasa Medical Faculty
Istanbul, 34098, Turkey (Türkiye)
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Medizinische Hochschule Hannover
Hanover, 30625, Germany
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Medizinische Universität Innsbruck
Innsbruck, 6020, Austria
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Ondokuz Mayis Univ. Med. Fac.
Samsun, 55139, Turkey (Türkiye)
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Ospedale Pediatrico Bambino Gesù
Roma, 00165, Italy
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Rainbow Babies and Children's Hospital
Cleveland, Ohio, 44106, United States
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Royal Manchester Children's Hospital
Manchester, Greater Manchester, M13 9WL, United Kingdom
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SAIH "Kemerovo Regional Clinical Hospital"
Kemerovo, 650066, Russia
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SBEI HPE Altai State Medical University of MoH and SD
Barnaul, 656038, Russia
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SI Institute of Blood Pathology and Transfusion Medicine of NAMSU
Lviv, 79044, Ukraine
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St. Jude Affiliate Clinic at Novant Health
Charlotte, North Carolina, 28204, United States
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Texas Children's Cancer and Hematology Center
Houston, Texas, 77030, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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UZ Leuven
Leuven, 3000, Belgium
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Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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University of Colorado Hemophilia & Thrombosis Center
Aurora, Colorado, 80045, United States
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University of Florida College of Medicine
Jacksonville, Florida, 32610, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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Werlhof-Institut GmbH
Hanover, 30159, Germany
Conditions
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