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Can a chinese fruit powder shrink artery plaques?

NCT ID NCT07840950

Disease control Sponsor: Xiangya Hospital of Central South University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers are testing whether Rosa roxburghii freeze-dried powder, a fruit supplement from traditional Chinese medicine, can reduce carotid artery plaques when added to standard care. The study enrolls 200 adults aged 40 to 80 who have at least one carotid plaque. Half receive standard anti-atherosclerosis drugs alone, and half receive those drugs plus 3 grams of the powder daily for six months. The team measures plaque size by ultrasound and checks cholesterol, inflammatory markers, gut bacteria, and blood metabolites.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rosa roxburghii freeze-dried juice powder, a fruit supplement used in traditional Chinese medicine
What this could lead to
If it works, this could offer a low-cost supplement that helps shrink carotid plaques when added to standard heart medicines.
What could go wrong
This is a single-center study of 200 people, and supplement effects on plaque size are often small. Rosa roxburghii may add nothing beyond statins and antiplatelet drugs, and it can still cause side effects or interact with prescriptions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants clinically diagnosed with atherosclerosis (AS) by a specialist physician * Age between 40 and 80 years * Presence of at least one identifiable carotid plaque meeting all of the following criteria: (a) a focal structure protruding into the lumen; (b) on gray-scale ultrasound longitudinal/transverse sections, protrusion beyond the vascular intimal surface with a maximum thickness ≥ 1.5 mm compared with the adjacent normal vessel wall (1-2 cm proximal or distal to the plaque); (c) a local structure protruding into the lumen with a thickness ≥ 0.5 mm or \> 50% of the surrounding intima-media thickness (IMT), accompanied by abnormal lipid metabolism markers * Diagnosis of carotid plaque and regular follow-up with the same physician at the study site * Willingness to refrain from participating in other clinical studies and to complete the full treatment regimen during the study period * Voluntarily sign the informed consent form after being fully informed Exclusion Criteria: * History of allergy to Rosa roxburghii juice or vitamin C preparations * Hyperlipidemia without detectable carotid plaques * Severe malnutrition * Concomitant liver or kidney disease * Pregnancy or lactation * Psychiatric disorders or inability to cooperate with the study procedures * Diagnosis of diabetes mellitus or hypertension * Use of antibiotics, probiotics, prebiotics, laxatives, or traditional Chinese medicine within 3 months prior to enrollment * Any condition that, in the investigator's opinion, makes the participant unsuitable for enrollment

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Conditions

The condition(s) this trial relates to.

atherosclerosis carotid artery disorder carotid stenosis ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atherosclerosis Carotid artery plaques Ischemic stroke

How to take part

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  1. The official record

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