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New drug duo aims to slow rare spleen cancer

NCT ID NCT05735834

Ongoing Disease control Sponsor: International Extranodal Lymphoma Study Group (IELSG) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether adding zanubrutinib to standard rituximab works better than rituximab alone for people with a rare lymphoma of the spleen (SMZL) who haven't had treatment yet. About 122 participants will receive either the combo or rituximab alone for up to two years, with follow-up for three years. The main goal is to see if the combination keeps the cancer from growing longer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

splenic marginal zone lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPLENIC MARGINAL ZONE LYMPHOMA

Contacts and locations

Locations

  • A.O.U. Policlinico G. Rodolico-S. Marco

    Catania, 95123, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • ASST Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello

    Palermo, 90146, Italy

  • Azienda Ospedaliero Universitaria Maggiore della Carità

    Novara, 28100, Italy

  • CHRU Nancy Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU de Grenoble

    Grenoble, 38043, France

  • Churchill Hospital

    Oxford, OX3 7LE, United Kingdom

  • Clatterbridge Cancer Centre

    Liverpool, L7 8YA, United Kingdom

  • Clinica Universidad de Navarra

    Madrid, Spain

  • Clinica Universidad de Navarra

    Pamplona, Spain

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Guy's Hospital - Guy's and St. Thomas' NHS Foundation Trust

    London, SE1 9RT, United Kingdom

  • Hospedal Clinic de Barcelona

    Barcelona, Spain

  • Hospital 12 De Octubre

    Madrid, Spain

  • Hospital Beatson West of Scotland Cancer Centre

    Glasgow, G12 0YN, United Kingdom

  • Hospital Clinico De Valencia

    Valencia, Spain

  • Hospital De Donostia

    San Sebastián, Spain

  • Hospital De Salamanca

    Salamanca, Spain

  • Hospital Gregorio Marañón

    Madrid, Spain

  • Hospital Ramon y Cajal

    Madrid, Spain

  • Hospital Universitario Cruces

    Bilbao, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, Spain

  • Hospital Vall d'Hebron

    Barcelona, Spain

  • Hospital Virgen Arrixaca

    El Palmar, Spain

  • Hospital del Mar

    Barcelona, Spain

  • Hôpital Lyon-Sud

    Pierre-Bénite, 69495, France

  • Hôpital Saint Louis

    Paris, 75475, France

  • INSELSPITAL, Bern University Hospital

    Bern, 3010, Switzerland

  • IRCCS AOU di Bologna

    Bologna, 40138, Italy

  • IRCCS IRST Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"

    Meldola, 47014, Italy

  • IRCCS Istituto Tumori Giovanni Paolo II

    Bari, 70124, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • IRCCS Policlinico San Matteo

    Pavia, Italy

  • Institut Bergonié

    Bordeaux, 33076, France

  • Istitut Català d'Oncologia, Hospital Duran i Reynals

    Barcelona, Spain

  • Karolinska University Hospital

    Stockholm, Sweden

  • Medical University of Vienna

    Vienna, Austria

  • Oncology Institute of Southern Switzerland

    Bellinzona, 6500, Switzerland

  • Oslo University Hospital

    Oslo, Norway

  • Ospedale Santa Maria delle Croci

    Ravenna, 48121, Italy

  • Ospedale di Circolo e Fondazione Macchi - ASST dei Sette Laghi

    Varese, 21100, Italy

  • Policlinico Santa Maria alle Scotte

    Siena, 53100, Italy

  • The Christie

    Manchester, M20 4BX, United Kingdom

  • The Royal Marsden NHS Foundation Trust

    Sutton, SM2 5PT, United Kingdom

  • USL-IRCCS of Reggio Emilia, Arcispedale Santa Maria Nuova

    Reggio Emilia, 42123, Italy

  • University College London Hospitals

    London, NW1 2PG, United Kingdom

  • University Hospital of Wales

    Cardiff, CF14 4XW, United Kingdom

  • University Hospitals Dorset

    Bournemouth, BH7 7DW, United Kingdom

More trials for these conditions

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