New eye drops aim to soothe dry eyes

NCT ID NCT06244316

Completed Symptom relief Sponsor: Dompé Farmaceutici S.p.A Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested two strengths of rhNGF eye drops against a placebo in 317 adults with moderate-to-severe dry eye disease. Participants used the drops three times a day for 4 weeks, followed by 4 weeks of monitoring. The goal was to see if the drops could improve dry eye symptoms and increase tear production better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: recombinant human nerve growth factor (rhNGF) eye drops
What this could lead to: If it works, this could lead to a new treatment option that eases dry eye symptoms and improves tear production.
What could go wrong: This is a phase 2 trial, so results are still early. The treatment may not prove better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE DISEASE

Contacts and locations

Locations

Arizona Eye Center

Chandler, Arizona, 85224, United States
Azienda Ospedaliera Universitaria Policlinico G Martino

Messina, 98124, Italy
Azienda Ospedaliero Universitario Policlinicol Umberto I

Roma, 00161, Italy
East West Eye Institute

Torrance, California, 90505, United States
Eye Associates of North Jersey

Dover, New Jersey, 07801, United States
Eye Consultants of Atlanta

Atlanta, Georgia, 30339, United States
Fondazione Policlinico Universitario Campus Bio-Medico di Roma

Roma, 00128, Italy
New England Eye Center - Boston

Boston, Massachusetts, 02111, United States
Ospedale S. Giuseppe Multimedica

Milan, 20123, Italy
Sibia Eye Institute

Boynton Beach, Florida, 33437, United States
The Scheie Eye Institute

Philadelphia, Pennsylvania, 19104, United States
Total Eye Care PA

Memphis, Tennessee, 38119, United States
Toyos Clinic

Nashville, Tennessee, 37215, United States
Vision Institute - Fontanero St

Colorado Springs, Colorado, 80907, United States

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