New drug could ease bulging eyes in thyroid disease

NCT ID NCT06625398

Ongoing Disease control Sponsor: Viridian Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests an investigational drug called VRDN-003 in 204 people with chronic thyroid eye disease (TED). The drug is given as a shot under the skin and aims to reduce eye bulging and other symptoms. Participants are randomly assigned to receive either VRDN-003 or a placebo, and neither they nor their doctors know which they receive. The study is active but not recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VRDN-003 (a drug that blocks a specific receptor to reduce inflammation and tissue swelling)
What this could lead to: If it works, this could provide a new treatment option for people with chronic thyroid eye disease, reducing eye bulging and discomfort without the need for surgery.
What could go wrong: This is a phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is also only for people with chronic TED, not for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos Graves Ophthalmopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THYROID EYE DISEASE

Contacts and locations

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Locations

A.P.J. Office

Newport Beach, California, 92660, United States
Advancing Research International, LLC

Los Angeles, California, 90023, United States
Agile Clinical Research Trials, LLC

Atlanta, Georgia, 30328, United States
Alliance Research Institute - Canoga Park

Canoga Park, California, 91304, United States
Alliance Research Institute - Lynwood

Lynwood, California, 90262, United States
Anmed Health Services LLC

Miami, Florida, 33193, United States
Asheville Clinical Research

Asheville, North Carolina, 28803, United States
Baylor College of Medicine/Alkek Eye Center

Houston, Texas, 77030, United States
Byers Eye Institute at Stanford University

Palo Alto, California, 94303, United States
Duke Eye Center

Durham, North Carolina, 27710, United States
Fraser Eye Care Center

Fraser, Michigan, 48026, United States
Gulf Coast Clinical Trials

Houston, Texas, 77070, United States
Horizon Clinical Research Group

Cypress, Texas, 77429, United States
Hype Clinical Research LLC

Miami, Florida, 33145, United States
Ilumina Medical Research

Kissimmee, Florida, 34744, United States
Kahana Oculoplastic & Orbital Surgery

Livonia, Michigan, 48152, United States
Marvel Clinical Research

Huntington Beach, California, 92647, United States
Massachusetts Eye and Ear

Boston, Massachusetts, 02114, United States
Med-Care Research

Miami, Florida, 33125, United States
Neuro-Eye Clinical Trials

Houston, Texas, 77074, United States
Opthalmic Consultants of Boston

East Weymouth, Massachusetts, 02189, United States
Pasadena Clinical Trials

Pasadena, California, 91101, United States
Roski Eye Institute, Keck School of Medicine, USC

Los Angeles, California, 90033, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07103, United States
S.L. Office

Las Vegas, Nevada, 89144, United States
Sarasota Retina Institute

Sarasota, Florida, 34239, United States
Scheie Eye Institute Penn Presbyterian

Philadelphia, Pennsylvania, 19104, United States
Scottsdale Clinical Trials

Scottsdale, Arizona, 85260, United States
Senta Clinic

San Diego, California, 92108, United States
Southern Clinical Research LLc

Miami, Florida, 33990, United States
United Medical Research Institute

Inglewood, California, 90301, United States
University Health

Kansas City, Missouri, 64108, United States
University of Washington, Eye institute

Seattle, Washington, 98104, United States
Vector Clinical Trials

Sparks, Nevada, 89436, United States
Vision Medical Research

Orland Park, Illinois, 60462, United States
West Virginia University Eye Institute

Morgantown, West Virginia, 26506, United States
Wills Eye Hospital

Philadelphia, Pennsylvania, 19107, United States

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