New shot could ease bulging eyes in thyroid disease
NCT ID NCT06625411
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This Phase 3 trial tests an investigational drug called VRDN-003 for active thyroid eye disease, a condition that causes eye bulging, redness, and discomfort. The study involves 132 adults with moderate to severe symptoms. Participants receive either VRDN-003 or a placebo as a shot under the skin. The main goal is to see if the drug reduces eye bulging by at least 2 millimeters.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VRDN-003 (a monoclonal antibody targeting IGF-1 receptor)
What this could lead to
If it works, this could provide a new treatment option for thyroid eye disease, reducing eye bulging and discomfort without the need for intravenous infusions.
What could go wrong
This is an early Phase 3 trial with only 132 participants, so results may not apply to everyone. The drug is still investigational, and side effects or lack of effectiveness are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.P.J. Office
Newport Beach, California, 92660, United States
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Advancing Research International, LLC
Los Angeles, California, 90023, United States
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Agile Clinical Research Trials, LLC
Atlanta, Georgia, 30328, United States
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Alliance Research Institute - Canoga Park
Canoga Park, California, 91304, United States
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Alliance Research Institute - Lynwood
Lynwood, California, 90262, United States
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Anmed Health Services LLC
Miami, Florida, 33193, United States
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Asheville Clinical Research
Asheville, North Carolina, 28803, United States
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Baylor College of Medicine/Alkek Eye Center
Houston, Texas, 77030, United States
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Byers Eye Institute at Stanford University
Palo Alto, California, 94303, United States
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C&A Clinical Trials Corp
Cape Coral, Florida, 33990, United States
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Continental Clinical Research
Miami, Florida, 33144, United States
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Duke Eye Center
Durham, North Carolina, 27705, United States
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Fraser Eye Care Center
Fraser, Michigan, 48026, United States
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Gulf Coast Clinical Trials
Houston, Texas, 77070, United States
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Hype Clinical Research LLC
Miami, Florida, 33145, United States
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Ilumina Medical Research
Kissimmee, Florida, 34744, United States
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Kahana Oculoplastic & Orbital Surgery
Livonia, Michigan, 48152, United States
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Marvel Clinical Research
Huntington Beach, California, 92647, United States
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Med-Care Research
Miami, Florida, 33125, United States
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Neuro-Eye Clinical Trials
Houston, Texas, 77074, United States
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Opthalmic Consultants of Boston
East Weymouth, Massachusetts, 02189, United States
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Pasadena Clinical Trials
Pasadena, California, 91101, United States
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Roski Eye Institute, Keck School of Medicine, USC
Los Angeles, California, 90033, United States
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Rutgers New Jersey Medical School
Newark, New Jersey, 07103, United States
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S.L. Office
Las Vegas, Nevada, 89144, United States
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Sarasota Retina Institute
Sarasota, Florida, 34239, United States
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Scottsdale Clinical Trials
Scottsdale, Arizona, 85260, United States
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Senta Clinic
San Diego, California, 92108, United States
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United Medical Research Institute
Inglewood, California, 90301, United States
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University Health
Kansas City, Missouri, 64108, United States
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University of Washington, Eye institute
Seattle, Washington, 98104, United States
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Vector Clinical Trials
Sparks, Nevada, 89436, United States
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Vision Medical Research
Orland Park, Illinois, 60462, United States
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West Virginia University Eye Institute
Morgantown, West Virginia, 26506, United States