Why do some lung patients bounce back to hospital? 500-Person study hunts for clues
NCT ID NCT05095090
First seen Oct 06, 2026 · Last updated Oct 07, 2026 · Updated 1 time
Summary
Researchers at the University of Leicester are following 500 people admitted to hospital with acute respiratory conditions such as pneumonia, asthma attacks, and COPD flare-ups. The study also includes people with chronic lung disease seen in outpatient clinics and healthy volunteers without lung disease. Over up to three years, participants complete questionnaires, physical function and muscle strength tests, lung function tests, activity monitoring, and biological sample collection. The goal is to find which characteristics predict readmission, length of stay, recovery, and survival.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If researchers identify which measurements predict poor recovery, doctors could target extra support to the patients who need it most after leaving hospital.
- What could go wrong
- This is an observational study, so it can show links but not prove cause and effect. Findings from 500 patients at one hospital network may not apply everywhere.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2022
- Expected to finish
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Oct 2033
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will include adults admitted to hospital with an acute respiratory condition, including exacerbations of an underlying physician-diagnosed chronic respiratory disease, as well as non-hospitalised patients under respiratory outpatient follow-up for a chronic respiratory condition. The study will also include healthy volunteers without chronic respiratory disease as a comparator group. Co-participation in other ethically approved studies, including interventional trials, is permitted.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria (Core study participants) 1. Hospital admission with an acute respiratory diagnosis, or currently under the care of hospital respiratory outpatient services for a chronic respiratory disease 2. Participant is willing \& able to give informed consent for participation in the study 3. Aged 18 years or above 4. Able (in the Investigators opinion) \& willing to comply with all study requirements Exclusion Criteria (Core study participants) 1. Unstable or life-threatening cardiac disease including myocardial infarction or unstable angina during current admission. 2. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. 3. Known pregnancy Inclusion Criteria (Healthy Controls) 1. Aged 18 years or above 2. No underlying respiratory disease as self-reported 3. Able (in the Investigators opinion) \& willing to comply with all study requirements Exclusion Criteria (Healthy Controls) 1. Hospitalised due to an acute respiratory illness in the last 6 weeks prior to consent 2. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. 3. Known pregnancy Additional inclusion and exclusion criteria for CHESTY sub-studies are detailed in the corresponding sub-study protocols.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Glenfield Hospital
RECRUITINGLeicester, LE3 9QP, United Kingdom
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