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Stoma-Free surgery for rectal cancer? new trial tests safety

NCT ID NCT07463261

Recruiting now Disease control Sponsor: ANO Scientific and Practical Club for the Development of Modern Medical Technologies Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether low-risk rectal cancer patients can safely undergo surgery without a temporary stoma (a bag attached to the belly to collect waste). The trial will compare leak rates in 442 patients who either get a stoma or not. If skipping the stoma is shown to be safe, it could mean fewer surgeries and better quality of life for many patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Preventive stoma (diverting ileostomy or transverse colostomy) versus no stoma
What this could lead to
If successful, this could show that many low-risk rectal cancer patients can safely avoid a temporary stoma, improving quality of life after surgery.
What could go wrong
This is a mid-stage trial with 442 participants, so results may not apply to all patients. There is a risk that skipping the stoma could lead to more anastomotic leaks, requiring emergency reoperation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anastomotic Leak rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCAL ADVANCED RECTAL CANCER LOW RECTAL CANCER MIDDLE RECTAL CANCER RECTAL CANCER SURGERY TME

Contacts and locations

Locations

  • Central Clinical Hospital of the Administrative Directorate of the President of the Russian Federation

    RECRUITING

    Moscow, Russia

  • Leningrad Regional Clinical Hospital

    RECRUITING

    Saint Petersburg, Russia

  • Moscow City Oncology Hospital No. 62 of the Moscow Department of Health

    RECRUITING

    Moscow, 143423, Russia

  • Republican clinical oncological center

    RECRUITING

    Ufa, Russia

  • State Autonomous Healthcare Institution of Nizhny Novgorod Region "Research Institute of Clinical Oncology "Nizhny Novgorod Regional Clinical Oncology Dispensary""

    RECRUITING

    Nizhny Novgorod, Russia

  • State Budgetary Institution of Healthcare of the city of Moscow "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow"

    RECRUITING

    Moscow, Russia

  • Sverdlovsk Regional Oncological Center

    RECRUITING

    Yekaterinburg, Russia

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