Can less be more? new trial aims to reduce side effects in testicular cancer treatment

NCT ID NCT03937843

Ongoing Disease control Sponsor: Swiss Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether reducing the intensity of chemotherapy and radiation can safely treat stage IIA/B seminoma, a type of testicular cancer. About 135 patients will receive either carboplatin alone or a combination of cisplatin and etoposide, along with lower-dose radiotherapy. The goal is to maintain cancer control while minimizing long-term side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin, cisplatin, and etoposide
What this could lead to: If successful, this could offer a safer treatment option for stage IIA/B seminoma with fewer side effects while still controlling the cancer.
What could go wrong: This is a phase 2 trial with only 135 participants, so results may not apply to all patients. Lowering treatment intensity could risk cancer recurrence.

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Conditions

The condition(s) this trial relates to.

seminoma testicular cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEMINOMA TESTICULAR CANCER

Contacts and locations

Locations

ASKLEPIOS Kliniken

Hamburg, 22763, Germany
Centre Hospitalier Universitaire Vaudois CHUV

Lausanne, CH-1011, Switzerland
Evang. Kliniken Essen-Mitte

Essen, 45136, Germany
Helios Klinikum Berlin-Buch

Berlin, 13125, Germany
Hopital de Sion

Sion, 1951, Switzerland
Inselspital Bern

Bern, 3010, Switzerland
Istituto Oncologico della Svizzera Italiana (IOSI)

Bellinzona, CH-6500, Switzerland
Kantonsspital - St. Gallen

Sankt Gallen, CH-9007, Switzerland
Kantonsspital Graubuenden

Chur, 7000, Switzerland
Kantonsspital Graubünden

Chur, 7000, Switzerland
Kantonsspital Winterthur

Winterthur, 8401, Switzerland
RKH Klinikum Ludwigsburg

Ludwigsburg, 71640, Germany
Rotkreuzklinikum München

München, München, 80364, Germany
Universitaetsspital-Basel

Basel, CH-4031, Switzerland
UniversitätsSpital Zürich

Zurich, 8091, Switzerland
Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany
Universitätsklinikum Tübingen

Tübingen, 72076, Germany
Universitätsklinikum Ulm

Ulm, 89075, Germany
Vivantes Klinikum Am Urban

Berlin, 10967, Germany

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