New pain block could cut opioid use after gynecologic surgery

NCT ID NCT06575699

Completed Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a rectus sheath block (a type of nerve block) using liposomal bupivacaine can reduce the need for opioid painkillers after gynecologic cancer surgery. Thirty patients received the block and were compared to 60 similar patients who had epidural pain relief. The main goal was to measure opioid use in the first 72 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal bupivacaine and bupivacaine hydrochloride
What this could lead to: If successful, this approach could offer a simpler, effective pain control method after gynecologic cancer surgery, potentially reducing opioid use and side effects.
What could go wrong: This is a small pilot study with only 30 participants receiving the block, compared to historical controls. Results may not apply to all patients, and the block may not be as effective as epidural analgesia.

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Conditions

The condition(s) this trial relates to.

female reproductive organ cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GYNECOLOGIC SURGICAL PROCEDURES

Contacts and locations

Locations

Duke University Medical Center

Durham, North Carolina, 27710, United States

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