New painkiller may reduce Post-Surgery nausea in women

NCT ID NCT07026162

Completed Symptom relief Sponsor: YanYing Xiao Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the painkiller oliceridine causes less nausea and vomiting than the standard drug sufentanil in women undergoing gynecologic laparoscopic surgery. Ninety-six participants received one of the two drugs during and after surgery. Researchers tracked nausea, vomiting, and side effects for 48 hours after the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oliceridine (also known as TRV130 or Olinvyk)
What this could lead to: If oliceridine works better, it could offer a new option for pain control with less nausea and vomiting after gynecologic surgery.
What could go wrong: This is a small, completed phase 4 trial with only 96 participants. Results may not apply to all patients, and oliceridine may not prove superior to the standard drug sufentanil.

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GYNECOLOGIC SURGICAL PROCEDURES LAPAROSCOPY POSTOPERATIVE NAUSEA AND VOMITING (PONV)

Contacts and locations

Locations

The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China

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