Could a common sedative stop post-surgery nausea?

NCT ID NCT07668700

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a low dose of midazolam (a sedative) to the usual two-drug combination (dexamethasone and ondansetron) could better prevent nausea and vomiting after gynecologic laparoscopic surgery. 300 women aged 19–65 took part. Half received the standard two drugs plus a placebo, and the other half received the standard two drugs plus midazolam. The main goal was to see if fewer patients had significant nausea (score under 4 on a 0–10 scale) in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
midazolam
What this could lead to
If it works, this could offer a better way to prevent nausea and vomiting after surgery, improving patient comfort and recovery.
What could go wrong
This is a small, single-center Phase 2 trial. The benefit may be modest, and midazolam can cause drowsiness or other side effects.

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Anaesthesiology

    Lahore, Punjab Province, 54590, Pakistan

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