Can Real-World data replace clinical trials? new study puts it to the test

NCT ID NCT07225790

Completed Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at whether information from routine medical records can produce the same results as a gold-standard clinical trial. Researchers analyzed data from 3,883 women with advanced breast cancer to see if real-world analyses could match the findings of the MONARCH-3 trial, which tested a drug combination. The goal is to learn when real-world data can be trusted for future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that real-world data can reliably reproduce clinical trial results, making future research faster and cheaper.
What could go wrong: This is an observational study, not a new treatment test. Results may not perfectly match the original trial due to differences in patient care and data quality.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02120, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.