Can Real-World data replace clinical trials? new study puts it to the test
NCT ID NCT07225790
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study looked at whether information from routine medical records can produce the same results as a gold-standard clinical trial. Researchers analyzed data from 3,883 women with advanced breast cancer to see if real-world analyses could match the findings of the MONARCH-3 trial, which tested a drug combination. The goal is to learn when real-world data can be trusted for future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could show that real-world data can reliably reproduce clinical trial results, making future research faster and cheaper.
What could go wrong
This is an observational study, not a new treatment test. Results may not perfectly match the original trial due to differences in patient care and data quality.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02120, United States