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New drug RAY121 tested for Long-Term safety in autoimmune patients

NCT ID NCT06723106

ENROLLING_BY_INVITATION Disease control Sponsor: Chugai Pharmaceutical Source: ClinicalTrials.gov ↗

First seen Apr 24, 2026 · Last updated May 16, 2026 · Updated 4 times

Summary

This study looks at the long-term safety of a drug called RAY121 in people with certain immune system diseases, such as antiphospholipid syndrome, bullous pemphigoid, and immune thrombocytopenia. About 144 participants who have already received four doses of RAY121 in a previous study and shown improvement will continue treatment. The main goal is to track any side effects over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "SHATHD" EAD Sofia

    Sofia, Sofia City Province, 1756, Bulgaria

  • AKH - Medizinische Universitaet Wien, Abteilung fuer Klinische Pharmakologie

    Vienna, 1090, Austria

  • AP-HP Hôpital Universitaire Pitié Salpêtrière

    Paris, Île-de-France Region, 75013, France

  • Box Hill Hospital

    Melbourne, Victoria, 3128, Australia

  • Campbelltown Public Hospital

    Sydney, New South Wales, 2560, Australia

  • Centro Clinico Academico Braga

    Braga, Braga District, 471-243, Portugal

  • Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.

    Vila Nova de Gaia, Porto District, 4434-502, Portugal

  • Centrul Medical Monza SRL

    Bucharest, Bucharest Municipality, 400015, Romania

  • Clinica Universidad de Navarra

    Pamplona, Community of Madrid & Navarre, 28027, Spain

  • Clinical Hospital Center "Sestre Milosrdnice"

    Zagreb, City of Zagreb, 10000, Croatia

  • DiIEX Recherche Sherbrooke, Inc

    Sherbrooke, Quebec, J1L 0H8, Canada

  • Diagnostic Consultation Center CONVEX EOOD

    Sofia, Sofia City Province, 1202, Bulgaria

  • Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital

    Ankara, Ankara, 06200, Turkey (Türkiye)

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka, 431-3192, Japan

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-0808, Japan

  • Hopital Lapeyronie,Service d'Immuno Rhumatologie

    Montpellier, Occitanie, 34295, France

  • Hospital Universitari Vall d'Hebron, Internal Medicine Dept.

    Barcelona, Province of Barcelona and Catalonia, 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 de October

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Ramon y Cajal, Servicio de Reumatologia

    Madrid, Madrid, 28034, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, Province Of Córdoba, 14004, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, Province Of Seville, 41013, Spain

  • IRCCS Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST

    Meldola, Forlì-Cesena Province, 47014, Italy

  • Institute Reumatologii I'm. Eleonory Reicher

    Warsaw, Masovian Voivodeship, 02-637, Poland

  • Institute of Science Tokyo Hospital

    Bunkyo-ku, Tokyo, 113-8519, Japan

  • Istanbul University Istanbul Medical Faculty

    Istanbul, Istanbul, 34093, Turkey (Türkiye)

  • Istituto Clinico Humanitas

    Milan, Milan Province, 20089, Italy

  • Kindai University Hospital

    Sakai, Osaka, 589-8511, Japan

  • National Center of Neurology and Psychiatry

    Kodaira, Tokyo, 187-8551, Japan

  • National Hospital Organization Kyushu Medical Center

    Fukuoka, 810-8563, Japan

  • National Hospital Organization Osaka Minami Medical Center

    Kawachi-Nagano, Osaka, 586-8521, Japan

  • National Hospital Organization Tokyo Medical Center

    Meguro-ku, Tokyo, 152-8902, Japan

  • National Taiwan University Hospital

    Taipei, 100229, Taiwan

  • Okayama University Hospital

    Okayama, 700-8558, Japan

  • Oncology Institute Prof. Dr. Ion Chiricuta I.O.C.N.

    Cluj-Napoca, Cluj, 11658, Romania

  • Osaka University Hospital

    Suita, Osaka, 565-0871, Japan

  • Ospedale San Giovanni Bosco

    Torino, Turin Province, 10154, Italy

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • Sanatorium Profesora Arenbergera

    Prague, Prague, 11000, Czechia

  • Semmelweis Egyetem

    Budapest, 1083, Hungary

  • Sorlandet sykehus Kristiansand

    Kristiansand, Agder County, 4604, Norway

  • Specialty Hospital Medico

    Rijeka, Primorje-Gorski Kotar County, 51000, Croatia

  • Stavanger Universitetssjukehus

    Stavanger, Rogaland County, 4011, Norway

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

    Szeged, Csongrád-Csanád County, 6720, Hungary

  • Taichung Veterans General Hospital

    Taipei, 407219, Taiwan

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • Toho University Omori Medical Center

    Ōta-ku, Tokyo, 134-8540, Japan

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • UMC Utrecht

    Utrecht, Utrecht Province, 3584 CX, Netherlands

  • UMHAT "Prof. Dr. St. Kirkovich", AD

    Stara Zagora, Stara Zagora Province, 6003, Bulgaria

  • Universitaetsklinikum Carl Gustav Carus TU Dresden, Klinik und Poliklinik f. Dermatologie

    Sachsen, Bundesländer, 1307, Germany

  • Universitaetsklinikum Erlangen

    Erlangen, Bavaria, 91054, Germany

  • Universitaetsklinikum Schleswig Holstein - Campus Luebeck, Klinik f Dermatologie, Allergologie u Venerologie

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitaetsmedizin Goettingen

    Göttingen, Göttingen District, 3075, Germany

  • University Medical Centre Groningen UMCG

    Groningen, Groningen Province, 9713 GZ, Netherlands

  • University hospital centre Zagreb

    Zagreb, City of Zagreb, 10000, Croatia

  • Westmead Hospital

    Sydney, New South Wales, 2145, Australia

Conditions

Explore the condition pages connected to this study.

ANTIPHOSPHOLIPID SYNDROME (APS) BEHÇET'S SYNDROME (BS) BEHÇET'S SYNDROME (BS) BULLOUS PEMPHIGOID (BP) DERMATOMYOSITIS (DM) IMMUNE THROMBOCYTOPENIA (ITP) IMMUNE-MEDIATED NECROTIZING MYOPATHY (IMNM)