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New hope for Hard-to-Treat lung cancer: targeted drug combo trial launches

NCT ID NCT06162221

Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study is testing new drugs called RAS(ON) inhibitors for people with advanced non-small cell lung cancer that has a RAS mutation. The goal is to see if these drugs are safe and can shrink tumors or slow the cancer's growth. About 616 adults who have already tried standard treatments will receive the drugs alone or with other therapies. This is an early-stage trial, so the main focus is safety and finding the right dose.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 616 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: All Patients (unless otherwise noted): * ≥ 18 years of age * ECOG PS is 0 to 1 * Adequate organ function as outlined by the study * Received prior standard therapy appropriate for tumor type and stage * Must have pathologically documented, locally advanced or metastatic KRAS G12C-mutated solid tumor malignancy (not amenable to curative surgery) (Subprotocol A) * Must have pathologically documented, locally advanced or metastatic RAS-mutated NSCLC (Subprotocol B) * Must have pathologically documented, locally advanced or metastatic RAS G12D-mutated NSCLC (Subprotocol C and Subprotocol D) Exclusion criteria: All Patients: * Primary central nervous system (CNS) tumors * Impaired gastrointestinal (GI) function that may significantly alter the absorption of RMC drugs * Major surgery \< 28 days of first dose * Active or history of interstitial lung disease (ILD) or pneumonitis requiring steroids Other inclusion/exclusion criteria may apply.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KRAS G12C-mutated solid tumors, lung cancer KRAS, NRAS, hras-mutated NSCLC Lung cancer stage IV, advanced solid tumor, cancer Non-small cell lung cancer (NSCLC) RAS G12D-mutated NSCLC

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    93 sites in 13 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • A.O.U. San Luigi Gonzaga-Orbassano - SCDU Oncologia Medica

    RECRUITING

    Orbassano, 10043, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    RECRUITING

    Milan, 20162, Italy

    Contact Email: •••••@•••••

  • Ambroise-Paré Hospital

    RECRUITING

    Boulogne, 92104, France

  • Banner MD Anderson Cancer Center

    RECRUITING

    Gilbert, Arizona, 85234, United States

  • Baptist Medical Center

    RECRUITING

    Memphis, Tennessee, 38120, United States

  • Boca Raton Clinical Research Associates

    RECRUITING

    Plantation, Florida, 33322, United States

  • CHU de Lille Institut Cœur Poumon

    RECRUITING

    Lille, Hauts-de-France, 59037, France

  • CHU de Nantes

    RECRUITING

    Nantes, Hauts-de-France, 44093, France

  • Cancer Specialists of North Florida

    RECRUITING

    Saint Augustine, Florida, 32086, United States

  • Centre François Baclesse

    RECRUITING

    Caen, 14076, France

  • Centre Georges François Leclerc

    RECRUITING

    Dijon, Bourgogne-Franche-Comté, 21079, France

  • Charite-Universitaetsmedizin Berlin - Campus Charite Mitte

    RECRUITING

    Berlin, 12203, Germany

  • Chi Mei Hospital, Liouying

    RECRUITING

    Tainan, 73657, Taiwan

  • Chris O'Brien Lifehouse Hosptial

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • City of Hope - Duarte

    RECRUITING

    Duarte, California, 91010, United States

  • City of Hope - Lennar

    RECRUITING

    Irvine, California, 92618, United States

  • Clinica Universidad de Navarra

    RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Clinical Research Alliance

    RECRUITING

    Westbury, New York, 11590, United States

  • Colorado Health Medical Group - Medical Oncology & Hematology

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

  • Complejo Hospitalario Universitario A Coruña

    RECRUITING

    A Coruña, 15006, Spain

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • EDOG - Institut Bergonié

    RECRUITING

    Bordeaux, New Aquitaine, 33000, France

  • Fondazione IRCCS Istituto Nazionale dei tumori

    RECRUITING

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario A Gemelli-Rome

    RECRUITING

    Rome, 00168, Italy

  • Fred Hutchinson Cancer Research Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Fundacion Instituto Valenciano de Oncologia

    RECRUITING

    Valencia, 46009, Spain

  • Georgetown University Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • H Lee Moffitt Cancer Center and Research Institute

    RECRUITING

    Tampa, Florida, 33612, United States

  • Henry Dunant Hospital Center

    RECRUITING

    Athens, 115 26, Greece

  • Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hopital Foch

    RECRUITING

    Suresnes, 92150, France

  • Hopital Tenon - AP-HP

    RECRUITING

    Paris, 75020, France

  • Hospices Civils de Lyon - Hôpital Louis Pradel

    RECRUITING

    Bron, Auvergne-Rhône-Alpes, 69500, France

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, Madrid, 28040, Spain

  • Hospital Regional Universitario de Malaga - Hospital Civil

    RECRUITING

    Málaga, 29011, Spain

  • Hospital Universitari Vall D' Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    RECRUITING

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Virgen del Rocio - PPDS

    RECRUITING

    Seville, 41014, Spain

  • Hôpital Cochin

    RECRUITING

    Paris, 75014, France

  • ICO Badalona - H.U. Germans Trias i Pujol

    RECRUITING

    Barcelona, 08916, Spain

  • IRCCS Instituto Nazionale tumori Ragina Elena

    RECRUITING

    Rome, 00144, Italy

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Institut Curie

    RECRUITING

    Paris, Île-de-France Region, 75005, France

  • Institut Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

  • Institut de Cancerologie de Ouest (ICO) - Angers

    RECRUITING

    Angers, 49055, France

  • Intermountain Health - St. Vincent Frontier Cancer Center

    RECRUITING

    Billings, Montana, 59102, United States

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l

    RECRUITING

    Meldola, Emilia-Romagna, 47014, Italy

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Krankenhaus Bethanien Moers

    RECRUITING

    Moers, 47441, Germany

  • Leiden University Medical Center

    RECRUITING

    Leiden, 2333 ZA, Netherlands

  • Linear Clinical Research

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Liverpool Hospital

    RECRUITING

    Liverpool, New South Wales, 2170, Australia

  • Lungenfachklinik Immenhausen

    RECRUITING

    Immenhausen, 34376, Germany

  • Monash Health

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • NEXT Oncology Dallas

    RECRUITING

    Irving, Texas, 75039, United States

  • NEXT Oncology Virginia

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • National Cancer Center

    RECRUITING

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • Nebraska Cancer Specialist

    RECRUITING

    Grand Island, Nebraska, 68803, United States

  • Nemocnice AGEL Novy Jicin a.s

    RECRUITING

    Nový Jičín, Czech Republic, 741 01, Czechia

  • New York University Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Odense University Hospital, Department of Oncology

    RECRUITING

    Odense, 5000, Denmark

  • Oncopole Claudius Regaud

    RECRUITING

    Toulouse, 31059, France

  • Ospedale Santa Maria Delle Croci

    RECRUITING

    Ravenna, 48121, Italy

  • Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

  • Royal North Shore Hospital

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Samsung Medical Center

    RECRUITING

    Seoul, Gangnam-gu, 06351, South Korea

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam-si, Gyeonggido, 13620, South Korea

  • Seoul St. Mary's Hospital, The Catholic University of Korea

    RECRUITING

    Seoul, Seocho-gu, 06591, South Korea

  • Severance Hospital

    RECRUITING

    Seoul, Seodaemun-Gu, 03722, South Korea

  • Stanford University - Stanford Cancer Institute

    RECRUITING

    Stanford, California, 94305, United States

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 40705, Taiwan

  • Taipei Municipal Wanfang Hospital

    RECRUITING

    Taipei, Wenshan Dist, 116, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • Tennessee Oncology

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The Netherlands Cancer Institute (NKI)

    RECRUITING

    Amsterdam, 1066, Netherlands

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Thoracic General Hospital of Athens "I SOTIRIA"

    RECRUITING

    Athens, 11527, Greece

  • Thoraxklinik Heidelberg gGmbH - Universitätsklinikum Heidelberg

    RECRUITING

    Heidelberg, 69126, Germany

  • UC Davis, Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

  • UCSF Medical Center - Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

    Contact Email: •••••@•••••

  • Uniklinik Köln

    RECRUITING

    Cologne, 50937, Germany

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University Medical Center Utrecht

    RECRUITING

    Utrecht, 3584, Netherlands

    Contact Email: •••••@•••••

  • University Medical Centre Groningen

    RECRUITING

    Groningen, 9713, Netherlands

  • University of California, San Diego Moores Cancer Center

    RECRUITING

    San Diego, California, 92037, United States

  • Universitätsklinikum Carl Gustav Carus an der TU Dresden

    RECRUITING

    Dresden, 01307, Germany

  • Universitätsklinikum Frankfurt

    RECRUITING

    Frankfurt am Main, 60590, Germany

  • Universitätsklinikum St. Pölten

    RECRUITING

    Sankt Pölten, Austria, 3100, Austria

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