A new strategy to tame lung cancer Drug's nerve pain?
NCT ID NCT07774520
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This trial tests whether starting with a lower dose of the lung cancer drug lazertinib, along with magnesium supplements, can reduce the nerve damage (numbness, tingling, pain) it often causes. The study includes people with EGFR-mutant non-small cell lung cancer who are starting first-line treatment. Participants are randomly assigned to receive either the standard dose, a lower dose, or a lower dose plus magnesium, and the rates of nerve damage are compared.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- lazertinib (reduced dose) and magnesium lactate supplementation
- What this could lead to
- If successful, this approach could offer a way to reduce nerve damage from lazertinib without losing its anti-cancer effect, improving quality of life for lung cancer patients.
- What could go wrong
- The trial is in phase 2, so it's not yet proven. Lowering the dose might reduce effectiveness, and magnesium may not fully prevent neuropathy. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 1,173 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Pathologically diagnosed pulmonary adenocarcinoma. 2. Patient with a stage not amenable to curative treatment by surgery or radiotherapy and requiring palliative chemotherapy. 3. Patient with no prior treatment history for lung cancer, or who relapsed \>=6 months after curative-intent therapy (concurrent chemoradiotherapy or adjuvant chemotherapy) with no subsequent anticancer treatment - i.e., a candidate for first-line chemotherapy. 4. Patient with a confirmed EGFR mutation of Exon 19 deletion or L858R. 5. Patient able to decide on participation in this study through voluntary decision-making. 6. Age 19 years or more. 7. ECOG PS 0-2. 8. Minimum life expectancy 12 weeks or more. 9. Adequate organ function. Exclusion Criteria: * Subjects with confirmed leptomeningeal/CNS metastasis on brain MRI or cerebrospinal fluid examination. * Subjects with pre-existing peripheral neuropathy. * Subjects who are taking any agent that may affect the development of peripheral neuropathy for reasons other than peripheral neuropathy (magnesium, pregabalin, gabapentin, duloxetine) and refuse to discontinue its use. * Subjects for whom, in the physician's judgment, participation in this study would carry greater harm than benefit (no specific items specified). * Uncontrolled systemic disease, including uncontrolled hypertension, severe heart failure, active bleeding, or active infection. * Pregnant or breastfeeding women. * History of interstitial lung disease (ILD), drug-induced ILD, radiation pneumonitis requiring steroid treatment, or evidence of clinically active ILD. * QTc prolongation based on QTc measured by ECG during the screening period (QTc \>=470 msec). * Subjects with a history of hypersensitivity to Magnes tablet. * Subjects with hereditary disorders of sugar metabolism such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. * Subjects with a history of severe symptomatic renal failure. * Subjects taking a drug expected to have a clinically significant interaction when co-administered with magnesium-containing preparations - such as phosphate preparations, calcium preparations, oral tetracyclines, antacids, or levodopa - for whom discontinuation or substitution of the drug is not possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Samsung Medical Center
RECRUITINGSeoul, Gang-nam Gu, 06351, South Korea
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