Orthodontic treatment may trigger cellular stress responses in children

NCT ID NCT07695584

Completed Knowledge-focused Sponsor: IRCCS Ospedale San Raffaele Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study investigates whether rapid maxillary expansion—a common orthodontic procedure to widen the upper jaw—causes changes in oxidative stress and antioxidant levels in children aged 10 to 13. Researchers measured specific biomarkers in gum fluid from 14 children undergoing the procedure and compared them to 14 untreated children. The goal is to understand the local biological response to the mechanical forces of expansion.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help orthodontists understand the biological effects of rapid maxillary expansion and potentially improve treatment protocols.
What could go wrong: This is a small pilot study with only 28 participants, so results may not apply to all patients. It measures biomarkers, not clinical outcomes, so direct treatment benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OXIDATIVE STRESS TRANSVERSE MAXILLARY DEFICIENCY

Contacts and locations

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Locations

Izmir Democracy University

Izmir, 35140, Turkey (Türkiye)

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