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New drug radiprodil tested for tough seizures in two brain conditions

NCT ID NCT06392009

Ongoing Disease control Sponsor: GRIN Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests an experimental drug called radiprodil in 30 people with tuberous sclerosis complex or focal cortical dysplasia type II whose seizures have not responded to at least two other medications. The study is open-label, meaning everyone gets the drug, and will check safety, how the body processes the drug, and whether it reduces seizures and behavioral symptoms over up to one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiprodil
What this could lead to
If it works, this could point toward a new treatment option for hard-to-control seizures in people with TSC or FCD type II.
What could go wrong
This is an early, small, open-label study with no placebo group, so results may not prove effectiveness. Side effects are still being identified.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Focal Cortical Dysplasia isolated focal cortical dysplasia isolated focal cortical dysplasia type II tuberous sclerosis tuberous sclerosis 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOCAL CORTICAL DYSPLASIA TUBEROUS SCLEROSIS COMPLEX

Contacts and locations

Locations

  • AOU Meyer

    Florence, Tuscany, 50139, Italy

  • Alberta Children's Hospital

    Calgary, T3A 2X6, Canada

  • Centrum Medyczne Plejady

    Krakow, 30363, Poland

  • Hospital Materno Infantil Sant Joan de Deu de Barcelona

    Barcelona, 08950, Spain

  • Hospital Ruber Internacional

    Madrid, 28034, Spain

  • Hospital Universitario Vall D´Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario Vithas La Milagrosa

    Madrid, 28010, Spain

  • IRCCS Istituto Giannina Gaslini

    Genoa, Liguria, 16146, Italy

  • Instytut Pomnik - Centrum Zdrowia Dziecka

    Warsaw, 04730, Poland

  • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)

    Roma, 00165, Italy

  • Queensland Children Hospital

    South Brisbane, 4101, Australia

  • The Hospital for Sick Children (Sick Kids)

    Toronto, M5G 1X8, Canada

  • UMC Uthrecht - Wilhelmina Kinderziekenhuis

    Utrecht, 3508, Netherlands

  • Universita Cattolica del Sacro Cuore - Policlinico Universitario "Agostino Gemelli"

    Roma, 00168, Italy

  • University Hospitals Bristol and Weston NHS Foundation Trust Bristol Royal Hospital for Children

    Bristol, BS2 8BJ, United Kingdom

  • University Hospitals Leuven, Pediatric Neurology

    Leuven, 3000, Belgium

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 60356, Poland

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80952, Poland

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