Zapping away recurrence: radiation after Dupuytren's treatment put to the test

NCT ID NCT06330545

Recruiting now Disease control Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial investigates whether targeted radiation therapy can stop Dupuytren's contracture from coming back after a collagenase injection and release procedure. Adults aged 45 and older with a finger that cannot lie flat will receive two 5-day courses of radiation separated by a rest period. Researchers will track recurrence over three years to see if the radiation makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy after collagenase injection and release
What this could lead to: If it works, this could offer a way to prevent Dupuytren's contracture from recurring after standard treatment, reducing the need for repeat procedures.
What could go wrong: This is a small, early-stage trial with no control group, so results may not be definitive. Radiation carries risks of skin irritation and other side effects.

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Conditions

The condition(s) this trial relates to.

palmar fibromatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUPUYTREN CONTRACTURE

Contacts and locations

Locations

Dartmouth Hitchcock
RECRUITING

Lebanon, New Hampshire, 03766, United States

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