Could beans and lentils beat red meat for a healthier heart?
NCT ID NCT05999136
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servings of red or processed meat per week. They are assigned to either keep their usual diet, swap red meat for pulses, or swap red meat for a mix of pulses and plant-based meat substitutes. The study measures changes in cholesterol, blood TMAO levels, and gut bacteria over time.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- pulses (beans, lentils, chickpeas, peas)
- What this could lead to
- If swapping red meat for pulses improves cholesterol and gut health, it could point toward a simple dietary change to lower heart disease risk.
- What could go wrong
- This is a small dietary intervention study, not a drug trial. Results may vary by individual and may not show clear benefits. Long-term adherence to the diet is uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Agricultural Sciences, Federico II University
Portici, 80055, Italy
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