Could beans and lentils beat red meat for a healthier heart?

NCT ID NCT05999136

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servings of red or processed meat per week. They are assigned to either keep their usual diet, swap red meat for pulses, or swap red meat for a mix of pulses and plant-based meat substitutes. The study measures changes in cholesterol, blood TMAO levels, and gut bacteria over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pulses (beans, lentils, chickpeas, peas)

What this could lead to

If swapping red meat for pulses improves cholesterol and gut health, it could point toward a simple dietary change to lower heart disease risk.

What could go wrong

This is a small dietary intervention study, not a drug trial. Results may vary by individual and may not show clear benefits. Long-term adherence to the diet is uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Obesity Overweight psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Agricultural Sciences, Federico II University

    Portici, 80055, Italy