Could a 'Pulse' of antibiotics ease Long-Term lyme symptoms?
NCT ID NCT06611111
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests whether giving the antibiotic ceftriaxone every 5 days for 6 weeks can safely reduce persistent symptoms like fatigue and pain in people who have already been treated for Lyme disease. About 44 adults aged 18 to 75 will receive either the drug or a placebo by IV. The main goal is to check safety and tolerability, with a secondary look at symptom improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ceftriaxone (an antibiotic)
What this could lead to
If it works, this could point toward a new way to ease lingering symptoms like fatigue and pain in people who have already been treated for Lyme disease.
What could go wrong
This is a very early, small Phase 1 trial focused on safety, not effectiveness. The drug may not improve symptoms, and side effects from repeated IV infusions are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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SUNY Upstate Medical University, Upstate Global Health Institute
RECRUITINGEast Syracuse, New York, 13057, United States