New drug PT0253 targets Hard-to-Treat KRAS G12D cancers
NCT ID NCT06797336
First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times
Summary
This early-phase study tests a new drug called PT0253 in about 115 adults with advanced solid tumors that have a specific genetic change called KRAS G12D. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. Participants must have tumors that have spread or cannot be removed by surgery and have not responded to other treatments.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSeoul, South Korea
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CHA University Bundang Medical Center
RECRUITINGSeongnam, South Korea
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Dana Farber/Massachusetts General Hospital, Inc
RECRUITINGBoston, Massachusetts, 02215, United States
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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New Experimental Therapeutics of San Antonio LLC
RECRUITINGSan Antonio, Texas, 78229, United States
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SCRI Lake Mary
WITHDRAWNNashville, Tennessee, 37203, United States
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SCRI Oncology Partners
WITHDRAWNNashville, Tennessee, 37203, United States
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START - South Texas Accelerated Research Therapeutics, LLC
RECRUITINGSan Antonio, Texas, 78229, United States
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START Los Angeles
RECRUITINGLos Angeles, California, 90025, United States
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
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Samsung Medical Center
RECRUITINGSeoul, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeoul, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, South Korea
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Severance Hospital, Yonsei University Health System
RECRUITINGSeoul, South Korea
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