New drug PT0253 targets Hard-to-Treat KRAS G12D cancers
NCT ID NCT06797336
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug called PT0253 in about 115 adults with advanced solid tumors that have a specific genetic change called KRAS G12D. The main goals are to check the drug's safety, find the best dose, and see how the body processes it. Participants must have tumors that have spread or cannot be removed by surgery and have not responded to other treatments.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana Farber/Massachusetts General Hospital, Inc
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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New Experimental Therapeutics of San Antonio LLC
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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SCRI Lake Mary
RECRUITINGNashville, Tennessee, 37203, United States
Contact
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
Contact
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START - South Texas Accelerated Research Therapeutics, LLC
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact