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Blood-derived injections may mend torn shoulder tendons without surgery

NCT ID NCT07789951

Disease control Sponsor: Taichung Veterans General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether injections of PRP lysate, a product made from a patient's own blood platelets, can improve shoulder pain, strength, and tendon tear size in adults with partial rotator cuff tears. Participants receive either PRP lysate or hypertonic dextrose prolotherapy, given as three monthly ultrasound-guided injections. Researchers measure changes in tear size, shoulder symptoms, and rotation strength before and after treatment to see if PRP lysate offers an advantage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PRP lysate (a platelet-rich plasma derivative) and hypertonic dextrose (a sugar solution used in prolotherapy)
What this could lead to
If PRP lysate works, it could offer a non-surgical way to ease shoulder pain, improve strength, and possibly shrink partial rotator cuff tears.
What could go wrong
This is a small early-stage trial with only 28 participants, so results may not apply broadly. The treatment involves injections, which carry risks like pain or infection, and it may not outperform dextrose prolotherapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Mar 2022

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age older than 20 years. * Shoulder pain with a partial-thickness rotator cuff tear confirmed by physical examination and ultrasonography. * Willing and able to provide written informed consent. Exclusion Criteria: * Adhesive capsulitis. * Previous shoulder surgery. * Neuromuscular disease affecting shoulder strength. * Platelet dysfunction. * Thrombocytopenia. * Hypofibrinogenemia. * Acute or chronic infectious disease. * History of chronic liver disease. * Current antiplatelet therapy. * Depression or other psychological problems. * Rheumatological disorders. * Cognitive impairment that would prevent adherence to the study protocol.

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Conditions

The condition(s) this trial relates to.

Rotator Cuff Injuries rotator cuff syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rotator cuff arthropathy of bilateral shoulders Rotator cuff arthropathy of left shoulder Rotator cuff arthropathy of right shoulder Rotator cuff syndrome Rotator cuff tear

Contacts and locations

Locations

  • Taichung Veterans General Hospital

    Taichung, Taiwan

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