New radioactive drug targets Hard-to-Treat prostate cancer

NCT ID NCT06229366

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This early-phase trial tests an experimental drug called [Ac-225]-PSMA-62 in men with prostate cancer that has spread and is no longer responding to standard treatments. The drug delivers a radioactive payload directly to cancer cells that have a specific marker (PSMA). The study aims to find the safest dose and check for side effects, while also looking at whether it can delay the need for lifelong hormone therapy. About 142 men with either hormone-sensitive or castration-resistant prostate cancer will take part.

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Contacts and locations

Locations

  • BC Cancer Vancouver

    Vancouver, V5Z4E6, Canada

  • Centre Hospitalier Universite de QUEBEC

    Québec, G1J 1Z4, Canada

  • Hopital De Chicoutimi

    Saguenay, G7H 5H6, Canada

  • Jewish General Hospital

    Montreal, H3T 1E2, Canada

  • Juravinski

    Hamilton, L8V 5C2, Canada

  • McGill University

    Montreal, H4A 3J1, Canada

  • Princess Margaret Cancer Centre

    Toronto, M5G 2M9, Canada

Conditions

Explore the condition pages connected to this study.