Blood DNA fragments and MRI join forces to spot hidden prostate cancer

NCT ID NCT06509919

Terminated Diagnosis Sponsor: Shanghai Changzheng Hospital Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether combining a blood test that analyzes DNA fragments (cfDNA) with MRI scans can better detect prostate cancer in men with borderline PSA levels (4–10 ng/mL). Researchers aim to build a prediction model that could reduce unnecessary biopsies. The study involves 1,600 men scheduled for prostate biopsy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Blood draw for plasma cfDNA whole genome sequencing and MRI scans
What this could lead to: If successful, this could provide a more accurate, non-invasive way to detect prostate cancer and reduce unnecessary biopsies.
What could go wrong: This is an early-stage diagnostic model that may not prove accurate enough in practice. The blood test and MRI are not treatments and carry no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

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Locations

Cancer Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China
Changzheng hospital

Shanghai, Shanghai Municipality, 201109, China
Jiangsu Provincial People's Hospital

Nanjing, Jiangsu, 210029, China
Ningbo No. 1 Hospital

Ningbo, Zhejiang, 315010, China
Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, 225001, China
Shanghai Changhai Hospital

Shanghai, Shanghai Municipality, 200433, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215006, China
West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China
Zhongda Hospital, Southeast University

Nanjing, Jiangsu, 210009, China

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