Could a simple hormone pill replace the ovulation shot?

NCT ID NCT07466199

Not yet recruiting Knowledge-focused Sponsor: Instituto Valenciano de Infertilidade de Lisboa Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study will test whether giving vaginal progesterone can trigger ovulation in healthy egg donors aged 18 to 33. Ten participants will receive progesterone during a mild stimulation cycle, and researchers will measure hormone levels and count mature eggs retrieved. The goal is to understand if progesterone alone can start the final egg maturation process.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vaginal micronized progesterone (Cyclogest 400 mg)
What this could lead to: If it works, this could point toward a simpler, more natural way to trigger ovulation in fertility treatments.
What could go wrong: This is a very small pilot study with only 10 participants, so results may not apply widely. It is early-stage research, not a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASSISTED REPRODUCTIVE TREATMENTS HORMONAL RESPONSE OOCYTE MATURATION OVARIAN FUNCTION OVULATION

Could a simple hormone pill replace the ovulation shot?

Summary

What this could mean

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As listed by the trial registrant

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