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Jawbone rescue: can a Blood-Based membrane save your smile after a tooth comes out?

NCT ID NCT07818447

Prevention Sponsor: Danae A. Apatzidou Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

When a tooth is removed, the jawbone underneath can shrink, which may make it harder to place a dental implant later. This trial tests two methods to limit that bone loss: one uses a bone graft plus a membrane made from the patient's own blood (platelet-rich fibrin), and the other uses a bone graft plus a standard resorbable barrier membrane. Researchers will compare both against natural healing in 51 adults who need a single tooth pulled due to gum disease, measuring changes in bone width and height over three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bone allograft combined with either a platelet-rich fibrin membrane or a resorbable barrier membrane
What this could lead to
If the PRF approach works as well as the standard barrier membrane, it could offer a simpler, possibly cheaper way to preserve jawbone after tooth extraction.
What could go wrong
This is a small, single-center study with 51 participants and a 3-month follow-up. The results may not apply to other clinics or longer timeframes, and the procedure carries typical risks of dental surgery such as infection or delayed healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 51 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Age ≥18 years. Requirement for extraction of a single tooth affected by periodontal disease. Presence of at least one adjacent tooth. Loss of the buccal alveolar bone wall involving up to 50% of the socket wall. Good general systemic health (American Society of Anesthesiologists ASA Physical Status I or II). Satisfactory oral hygiene. Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: Systemic diseases or medications known to affect bone or soft tissue healing (e.g., uncontrolled diabetes mellitus, osteoporosis treated with bisphosphonates, or immunosuppressive therapy). Heavy smoking (\>10 cigarettes/day). Pregnancy or breastfeeding. Presence of an acute infection or abscess at the extraction site. History of radiotherapy to the head and neck region. Inability or unwillingness to comply with the study protocol or attend scheduled follow-up visits.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontitis Remission, Spontaneous

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss* / therapy Alveolar bone resorption Alveolar bone resorption following tooth extraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aristotle University of Thessaloniki, School of Dentistry, Faculty of Health Sciences, Postgraduate Periodontology Department

    RECRUITING

    Thessaloniki, Thessaloniki, GR 54124, Greece

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