Can a simple stitch help twins stay in the womb longer?

NCT ID NCT07372495

Recruiting now Prevention Sponsor: National Hospital of Obstetrics and Gynecology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches to prevent preterm birth in women carrying twins who have a short cervix. One group gets a cervical stitch (cerclage) plus vaginal progesterone, while the other gets progesterone alone. Researchers will track which group has fewer births before 28 weeks, aiming to find the best way to protect these babies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cervical cerclage (a stitch to close the cervix) and vaginal progesterone (hormone medication)
What this could lead to: If it works, this could give doctors a better way to prevent early delivery in twin pregnancies, reducing health risks for babies.
What could go wrong: This is a mid-stage trial with 260 participants, so results may not apply to all. The procedure carries small risks like infection or bleeding, and the combination may not be more effective than progesterone alone.

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Conditions

The condition(s) this trial relates to.

Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRETERM

Contacts and locations

Locations

Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
NOT_YET_RECRUITING

Bac Ninh, 220000, Vietnam
Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
NOT_YET_RECRUITING

Bac Ninh, 220000, Vietnam
Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam
NOT_YET_RECRUITING

Hung Yen, 160000, Vietnam
National Hospital of Obstetrics and Gynecology
RECRUITING

Hanoi, 100000, Vietnam
Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam
NOT_YET_RECRUITING

Ninh Binh, 430000, Vietnam
Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam
NOT_YET_RECRUITING

Quang Ninh, 200000, Vietnam

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