Heart shield for lymphoma patients: new trial aims to stop Chemo-Induced heart failure
NCT ID NCT06220032
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the drug dexrazoxane can prevent heart damage caused by chemotherapy in people with diffuse large B-cell lymphoma (DLBCL). About 324 patients will receive either standard treatment plus dexrazoxane or standard treatment alone. The goal is to see if dexrazoxane reduces the risk of heart failure, a serious side effect that can occur years after treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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NL-Almelo-ZGTALMELO
RECRUITINGAlmelo, Netherlands
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NL-Amstelveen-AMSTELLAND
RECRUITINGAmstelveen, Netherlands
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NL-Apeldoorn-GELREAPELDOORN
RECRUITINGApeldoorn, Netherlands
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NL-Arnhem-RIJNSTATE
RECRUITINGArnhem, Netherlands
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NL-Breda-AMPHIA
RECRUITINGBreda, Netherlands
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NL-Delft-RDGG
RECRUITINGDelft, Netherlands
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NL-Den Bosch-JBZ
RECRUITING's-Hertogenbosch, Netherlands
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NL-Den Haag-HAGA
RECRUITINGThe Hague, Netherlands
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NL-Dordrecht-ASZ
RECRUITINGDordrecht, Netherlands
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NL-Eindhoven-CATHARINA
RECRUITINGEindhoven, Netherlands
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NL-Eindhoven-MAXIMAMC
RECRUITINGEindhoven, Netherlands
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NL-Goes-ADRZ
RECRUITINGGoes, Netherlands
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NL-Groningen-MARTINI
RECRUITINGGroningen, Netherlands
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NL-Harderwijk-STJANSDALHARDERWIJK
RECRUITINGHarderwijk, Netherlands
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NL-Hilversum-TERGOOI
RECRUITINGHilversum, Netherlands
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NL-Hoofddorp-SPAARNEGASTHUIS
RECRUITINGHoofddorp, Netherlands
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NL-Nieuwegein-ANTONIUS
RECRUITINGNieuwegein, Netherlands
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NL-Nijmegen-CWZ
RECRUITINGNijmegen, Netherlands
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NL-Rotterdam-IKAZIA
RECRUITINGRotterdam, Netherlands
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NL-Schiedam-FRANCISCUSVLIETLAND
RECRUITINGSchiedam, Netherlands
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NL-Sittard-ZUYDERLAND MC
RECRUITINGSittard, Netherlands
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NL-Sneek-ANTONIUSSNEEK
RECRUITINGSneek, Netherlands
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NL-Utrecht-UMCUTRECHT
RECRUITINGUtrecht, Netherlands
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NL-Venlo-VIECURI
RECRUITINGVenlo, Netherlands
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NL-Zwolle-ISALA
RECRUITINGZwolle, Netherlands
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Other studies related to the condition(s) this trial covers.
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- Engineered immune cells take aim at Hard-to-Treat lymphomas
- Can a targeted pill boost Chemotherapy's punch against lymphoma?
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?
- Can a Four-Pronged attack beat brain lymphoma?