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Two quick breathing tests could spare ICU patients from failed ventilator removal

NCT ID NCT07786519

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This study looks at whether two simple measurements taken during a breathing trial can predict if a patient will need to be put back on a ventilator within three days. The measurements, called P0.1 and ΔPocc, reflect how hard the patient's breathing muscles are working. The goal is to help doctors decide more accurately when it is safe to remove a breathing tube, avoiding both premature removal and unnecessary prolonged ventilation. The study will follow 225 adults in the ICU who are ready to try breathing on their own.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Measurement of airway occlusion pressure parameters (P0.1 and ΔPocc) during a spontaneous breathing trial
What this could lead to
If these simple tests prove reliable, doctors could better predict which patients can safely come off a ventilator, reducing complications and ICU stays.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The measures may not be accurate enough in all patients, and results may not apply beyond this specific ICU setting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

225 people

The number who actually took part.

Started

Apr 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study was conducted in four critical care units in the Brittany region of France over a 12-month period, using the ventilators available at each center without specific selection, to best reflect usual clinical practices: a tertiary academic surgical ICU at Rennes University Hospital (30 beds) and three general ICUs at Saint-Brieuc Hospital (21 beds), Saint-Malo Hospital (15 beds), and Vannes Hospital (20 beds).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult patients meeting all the weaning criteria set out in the consensus of the International Conference on Weaning: * Duration of mechanical ventilation prior to the first weaning trial \> 24 hours * Respiratory rate ≤ 35 breaths/min, * Adequate oxygenation defined as SpO₂ ≥ 90% with FiO₂ ≤ 0.4 or PaO₂/FiO₂ ≥ 150 mm Hg with PEEP ≤ 8 cmH₂O, * Adequate cough reflex, * A conscious patient who is responsive to commands and has a RASS (Richmond Agitation Sedation Scale) score between +1 and -2 * Haemodynamically stable without vasopressors or on a minimal dose (noradrenaline \<0.1 µg/kg/min) * Patient informed about the study and expressing no objection to participating Exclusion Criteria: * Patients with neurological injury and a Glasgow Motor Score of ≤ M5 * Decision not to reintubate in the event of extubation failure * Adults subject to legal protection (judicial protection, curatorship, guardianship), and persons deprived of their liberty

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weaning mechanical ventilation

Contacts and locations

Locations

  • CHU de Rennes

    Rennes, France

  • Centre Hospitalier Bretagne Atlantique

    Vannes, France

  • Centre hospitalier de Saint Brieuc

    Saint-Brieuc, France

  • Centre hospitalier de Saint Malo

    St-Malo, France

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