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Could a computer model forecast aortic repair outcomes?

NCT ID NCT07779291

Knowledge-focused Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This study looks at whether detailed imaging and blood-flow simulations can predict how the aorta remodels after a procedure called TEVAR, used to treat type B aortic dissection. Researchers will analyze CT scans from 1,000 patients who had the procedure, using advanced mapping to track changes in the aorta and computer models to simulate blood flow. The goal is to build a tool that helps identify patients at higher risk of complications, such as aneurysm growth or rupture, so doctors can tailor follow-up care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Thoracic endovascular aortic repair (TEVAR) with stent-graft, plus imaging-based analysis using vascular deformation mapping and computational fluid dynamics
What this could lead to
If successful, this could give doctors a way to predict which patients are at high risk of complications after TEVAR, enabling earlier and more personalized follow-up care.
What could go wrong
This is a retrospective analysis, not a controlled trial, so it can identify associations but not prove cause and effect. The predictive model may not be accurate enough for routine clinical use without further validation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,000 people

The number who actually took part.

Started

Jan 2020

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study population comprises patients diagnosed with acute uncomplicated Type B aortic dissection who underwent thoracic endovascular aortic repair (TEVAR) at a single center. Eligible patients were aged 18 to 85 years, male or non-pregnant female, and had at least one preoperative and three postoperative CTA examinations with adequate imaging coverage from the brachiocephalic trunk to the iliac arteries. Patients with traumatic or iatrogenic dissection, chronic or complicated dissection, penetrating aortic ulcer (PAU), intramural hematoma (IMH), localized dissection, connective tissue disorders (e.g., Marfan syndrome), prior cardiac or aortic surgery, insufficient imaging quality, or failed image registration for VDM analysis were excluded. A total of 1000 patients were enrolled and followed for up to 5 years post-TEVAR to assess adverse aortic remodeling outcomes.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: (1) Age between 18 and 85 years, male or non-pregnant female. (2) CTA-confirmed diagnosis of Type B aortic dissection, classified as acute uncomplicated dissection. (3) Underwent TEVAR (thoracic endovascular aortic repair) procedure. (4) At least one preoperative and three postoperative CTA examinations available, with imaging coverage extending cranially to include the brachiocephalic trunk, left common carotid artery, and the origin of the left subclavian artery, and caudally to cover the origins of the internal and external iliac arteries. Exclusion Criteria: (1) Age \<18 or \>85 years. (2) Traumatic or iatrogenic dissection, or isolated aortic aneurysm. (3) Chronic or complicated dissection. (4) Penetrating aortic ulcer (PAU) or intramural hematoma (IMH), as well as localized dissection. (5) Connective tissue disorders, such as Marfan syndrome. (6) Prior history of cardiac or aortic surgery. (7) Absence of signed surgical informed consent. (8) Insufficient CTA examinations or inadequate imaging coverage/quality. (9) Failure of image registration precluding completion of the VDM analysis workflow.

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Conditions

The condition(s) this trial relates to.

fleck corneal dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CFD TEVAR Type B aortic dissection

Contacts and locations

Locations

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325000, China

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310009, China

  • Zhongshan Hospital, Fudan University

    Shanghai, Shanghai Municipality, 200032, China

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