Could a daily pill help restore skin color in vitiligo?

NCT ID NCT06113445

Ongoing Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests an oral drug called povorcitinib in about 467 adults with nonsegmental vitiligo, a condition causing white patches on the skin. Participants take the drug or a placebo daily for 52 weeks to see if it safely improves skin color on the face and body. The goal is to find a new treatment option for this long-term skin condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Povorcitinib (oral tablet)
What this could lead to: If it works, this could offer a new daily pill to help restore skin color in people with vitiligo, reducing visible patches.
What could go wrong: This is a phase 3 trial, but results are not yet available. The drug may not work for everyone, and side effects are possible. It requires ongoing treatment, not a one-time fix.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

generalized vitiligo vitiligo

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NONSEGMENTAL VITILIGO

Contacts and locations

Locations

Allcutis Research, Llc

Beverly, Massachusetts, 01915, United States
Alliance Clinical Trials

Waterloo, Ontario, N2J 1C4, Canada
Beldio Research Gmbh

Memmingen, 87700, Germany
Bravis Ziekenhuis

Bergen op Zoom, 4624 VT, Netherlands
Cahaba Dermatology

Hoover, Alabama, 35244, United States
Care Clinic

Ottawa, Ontario, K1A 0K9, Canada
Carpe Diem Centrum Medycyny Estetycznej

Warsaw, 02-661, Poland
Center For Clinical Studies

Houston, Texas, 77004, United States
Centre Hospitalier Universitaire (Chu) - Hopital Henri Mondor

Bordeaux, 33075, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Saint - Andre

Bordeaux, 33075, France
Centre Hospitalier Universitaire de Liege - Sart Tilman

Liège, 04000, Belgium
Centro de Dermatologia de Monterrey

Monterrey, 64460, Mexico
Cleaver Medical Group

Cumming, Georgia, 30040, United States
Clinica Universidad de Navarra (Cun)

Madrid, 31008, Spain
Clinica de Enfermedades Cronicas Y de Procedimientos Especiales (Cecype)

Morelia, 58249, Mexico
Clinical Research Partners Llc Crp Richmond Forest Avenue Office Building Location

Richmond, Virginia, 23226, United States
Clinical Science Institute Clinical Research Specialists Inc

Santa Monica, California, 90404, United States
Clinique de Courlancy

Reims, 51100, France
Cliniques Universitaires Ucl Saint-Luc

Woluwe-Saint-Lambert, 01200, Belgium
Cura Clinical Research

Sherman Oaks, California, 91403, United States
Derm Research Center of New York Inc

Stony Brook, New York, 11790, United States
Derma-Study-Center Friedrichshafen Gmbh

Friedrichshafen, 88045, Germany
Dermapolis Medical Dermatology Center Dr N. Med. Edyta Gebska

Chorzów, 41-516, Poland
Dermatologische Gemeinschaftspraxis Dres. Quist

Mainz, 55128, Germany
Dermatology Associates of Plymouth Meeting

Plymouth Meeting, Pennsylvania, 19462, United States
Dermatology Research Institute

Calgary, Alberta, T2J 7E1, Canada
Dermatology Specialists of Spokane

Spokane, Washington, 99202, United States
Dermatology and Surgery Specialists of North Atlanta

Marietta, Georgia, 30068, United States
Dermedic Jacek Zdybski

Ostrowiec Świętokrzyski, 27-400, Poland
Dermeffects

London, Ontario, N6H 5L5, Canada
Dermodent Centrum Medyczne Aldona Czajkowska Rafa¿ Czajkowski

Osielsko, 86-031, Poland
Dokkyo Medical University Saitama Medical Center

Minamikoshigaya, 343-8555, Japan
Emc Instytut Medyczny Spolka Akcyjna-Euromedicare Szpital Specjalistyczny Z Przychodnia

Wrocaw, 54144, Poland
Empire Dermatology

East Syracuse, New York, 13057, United States
Encore Medical Research, Llc

Hollywood, Florida, 33021, United States
Enverus Medical Research

Surrey, British Columbia, V3V 0C6, Canada
Etg Warszawa

Warsaw, 02-777, Poland
Forcare Clinical Research

Tampa, Florida, 33613, United States
Great Lakes Research Group Inc

Bay City, Michigan, 48706, United States
Grupo Clínico Catei Sc

Providencia 5TA Seccion, Mexico
Hamamatsu University Hospital

Hamamatsu, 431-3192, Japan
Hopital Larrey

Toulouse, 31059, France
Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Burssel

Brussel/ Brussels/bruxelles, 01070, Belgium
Hospital Clinic I Provincial de Barcelona

Barcelona, 08036, Spain
Hospital Universitari Germans Trias I Pujol (Hugtp)

Badalona, 08916, Spain
Hospital Universitario Fundacion Alcorcon

Alcorcón, 28922, Spain
Hospital Universitario Ramon Y Cajal

Madrid, 28034, Spain
Hospital de Manises

Manises, 46940, Spain
Instituto de Investigaciones Aplicadas A La Neurociencia A.C

Durango, 34000, Mexico
International Clinical Research Tennessee Llc

Murfreesboro, Tennessee, 37130, United States
Jdr Dermatology Research

Las Vegas, Nevada, 89148, United States
Jordan Valley Dermatology Center

West Jordan, Utah, 84088, United States
Juntendo University Urayasu Hospital

Urayasu, 279-0021, Japan
Klinikum Der Johann Wolfgang Goethe University

Frankfurt am Main, 60590, Germany
Kobe University Hospital

Kobe, 6500017, Japan
Kochi Medical School Hospital

Nankoku, 783-8505, Japan
Leader Research

Burlington, Ontario, L7R 4H9, Canada
Medisearch Clinical Trials

Saint Joseph, Missouri, 64506, United States
Metro Boston Clinical Partners

Brighton, Massachusetts, 02135-3511, United States
Nagasaki University Hospital

Nagasaki, 852-8501, Japan
Nagoya City University Hospital

Nagoya, 467-8602, Japan
National Hospital Organization Okayama Medical Center

Okayama, 701-1192, Japan
National University Corporation - Tokyo Medical and Dental University (Tmdu)

Tokyo, 113-8519, Japan
Niigata University Medical and Dental Hospital

Niigata, 9518520, Japan
North York Research Inc.

North YORK, Ontario, M2M 4J5, Canada
Ntt Medical Center Tokyo

Shinagawa-ku, 141-8625, Japan
Olympian Clinical Research

Tampa, Florida, 33609, United States
Options Research Group, Llc

Kokomo, Indiana, 46901, United States
Osaka University Hospital

Suita, 565-0871, Japan
Panstwowy Instytut Medyczny Mswia

Warsaw, 02-507, Poland
Pivotal Research Solutions

Stonecrest, Georgia, 30038, United States
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Renaissance Research

Cape Coral, Florida, 33991, United States
Revival Research Institute, Llc Dermatology

Troy, Michigan, 48084, United States
Sadick Dermatology Sadick Research Group

New York, New York, 10075, United States
San Marcus Research Clinic Inc.

Miami Lakes, Florida, 33014, United States
Savin Medical Group, Rc

Miami, Florida, 33156, United States
Siena Medical Research Corporation

Ottawa, Ontario, K1A 0K9, Canada
Skin Health

Peterborough, Ontario, K9J 5K2, Canada
Skin Research of South Florida, Llc

Miami, Florida, 33173, United States
St. Marianna University School of Medicine Hospital

Kawasaki, 216-8511, Japan
Sutter Health Palo Alto Medical Foundation Pamf Sunnyvale Center

Sunnyvale, California, 94086, United States
Synexus Polska Sp Z Oo Oddzial W Czestochowie

Częstochowa, 42-202, Poland
Synexus Polska Sp Z Oo Oddzial W Lodzi

Lodz, 90-127, Poland
Synexus Polska Sp. Z O.O. Oddzial W Katowicach

Katowice, 40-040, Poland
Synexus Polska Sp. Z O.O. Oddzial W Warszawie

Warsaw, 02-672, Poland
Tohoku University Hospital

Sendai, 980-8574, Japan
Tokyo Medical University Hospital

Shinjuku-ku, 160-0023, Japan
Trials in Medicine S.C.

Deleg. Cuauhtemoc, 06700, Mexico
Universidad Autonoma de Nuevo Leon (Uanl) - Hospital Universitario Dr. Jose Eleuterio Gonzalez - Cen

Monterrey, 64660, Mexico
Universitair Ziekenhuis Gent (Uz Gent)

Ghent, 09000, Belgium
Universitatsklinikum Erlangen

Erlangen, 91054, Germany
University Hospital Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University of California Irvine

Irvine, California, 92697, United States
University of Texas Physicians - Bellaire Station

Bellaire, Texas, 77401, United States
Uniwersytecki Szpital Kliniczny Im. Fryderyka Chopina W Rzeszowie

Rzeszów, 35-055, Poland
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-214, Poland
Uva - Amc - Stichting Nederlands Instituut Voor Pigmentstoornissen (Snip) (Netherlands Institute For

Amsterdam, 1105 AZ, Netherlands
Wayne State University Physician Group Dermatology

Dearborn, Michigan, 48124, United States
Yamagata University Hospital

Yamagata, 990-9585, Japan

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