New pill shows promise for Hard-to-Treat breast cancer

NCT ID NCT04115306

Ongoing Disease control Sponsor: Phoenix Molecular Designs Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tests an experimental oral drug called PMD-026 in people with metastatic breast cancer that has spread and is no longer curable. The drug targets a protein called RSK2 found in some tumors. The trial will check safety and how well the drug works alone or with another hormone therapy (fulvestrant). About 61 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PMD-026 (oral targeted drug) and fulvestrant (hormone therapy)
What this could lead to: If successful, this could lead to a new oral treatment option for people with a specific type of advanced breast cancer that has stopped responding to other therapies.
What could go wrong: This is an early-phase trial with only 61 participants, so the drug may not prove effective or safe enough for wider use. Side effects are unknown at this stage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
City of Hope

Duarte, California, 91010, United States
City of Hope Chicago

Zion, Illinois, 60099, United States
City of Hope Orange County, Lennar

Irvine, California, 92618, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Ohio State University

Columbus, Ohio, 43210, United States
Profound Research

Farmington Hills, Michigan, 48334, United States
South Texas Accelerated Research Therapeutics

San Antonio, Texas, 78229, United States
University of California, Los Angeles (UCLA)

Los Angeles, California, 90095, United States

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