Can a drug cocktail wake up and destroy hidden HIV?

NCT ID NCT07384624

First seen Feb 03, 2026 · Last updated May 24, 2026 · Updated 12 times

Summary

This study tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and help the immune system clear it. 30 adults with well-controlled HIV will receive the drugs in two phases to measure safety and effectiveness. While the goal is a functional cure, participants must continue their regular antiretroviral therapy.

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Contacts and locations

Study contacts

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Locations

  • Amsterdam University Medical Center

    Amsterdam, Netherlands

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  • Erasmus MC

    Rotterdam, Netherlands

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    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Radboud University Medical Center

    Nijmegen, Netherlands

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  • University Medical Center Utrecht

    Utrecht, Netherlands

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Conditions

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