Can a phenytoin gel speed healing after oral cancer surgery?
NCT ID NCT07801157
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This trial tests whether applying a phenytoin-loaded hydrogel to surgical wounds can improve healing after oral cancer surgery. Adults with locally advanced oral squamous cell carcinoma who are having surgery to remove the tumor will receive either standard wound care or standard care plus the hydrogel. The study measures wound healing, complications, pain, and hospital stay to see if the gel offers any benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A topical hydrogel containing phenytoin sodium, applied to the surgical wound twice daily for seven days after oral cancer surgery.
- What this could lead to
- If it works, this could offer a simple, low-cost way to improve wound healing and reduce complications after oral cancer surgery.
- What could go wrong
- This is a small, early-stage trial with only 24 participants, so results may not apply broadly. Phenytoin can cause allergic reactions, and the hydrogel may not improve healing enough to matter.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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24 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with locally advanced oral squamous cell carcinoma eligible for oncologic resection and reconstruction . Participants were aged 18-80 years, they had no evidence of distant metastasis they demonstrated good general health, defined as a Karnofsky Performance Status \>70 or ASA physical status I-III Exclusion Criteria: Early-stage disease. Distant metastasis. Poor performance status. Uncontrolled diabetes mellitus. Phenytoin allergy. Collagen vascular diseases that could confound wound-healing outcomes. * phenytoin allergy * collagen vascular diseases that could confound wound healing outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Medicine
Al Mansurah, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.