Could a simple silicone ring prevent premature birth in twins?

NCT ID NCT02328989

Completed Prevention Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether placing a silicone pessary in the vagina could help prevent premature birth in twin pregnancies where the cervix is short. The trial included 324 women with twin pregnancies between 16 and 24 weeks. The pessary was left in place until delivery or removed at 36 weeks. The goal was to see if this simple device could reduce serious complications or death in newborns.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vaginal pessary (a silicone device placed in the vagina to support the cervix)
What this could lead to: If effective, this simple device could reduce the risk of premature birth and related health problems in twin pregnancies.
What could go wrong: This trial is completed but results may not show a clear benefit. The device may cause discomfort or infection, and its effectiveness in twins is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREGNANCY

Contacts and locations

Locations

CHI Poissy

Poissy, France
CHRU Lille

Lille, Lille, France
CHU Angers

Angers, France
CHU Bordeaux

Bordeaux, France
CHU Caen

Caen, France
CHU Nantes

Nantes, France
CHU Saint-Etienne

Saint-Etienne, France
CHU Toulouse

Toulouse, France, 31059, France
CHU Tours

Tours, France
GH Pitié Salpétriêre

Paris, France
Hôpital Antoine Béclère

Paris, France
Hôpital Bicêtre

Paris, France
Hôpital Marseille AP-HM

Marseille, France
Hôpital Necker

Paris, France
Hôpital Robert Debré

Paris, France
Hôpital Saint-Joseph

Marseille, Marseille, France
Hôpital Universitaire de Strasbourg

Strasbourg, France
Maternité Port-Royal Cochin

Paris, France

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