Immune cell therapy takes on rare blistering skin disease

NCT ID NCT04422912

Recruiting now Disease control Sponsor: Cabaletta Bio Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two types of engineered immune cells (CAR T cells) in 40 adults with active pemphigus vulgaris, a painful blistering skin condition. The cells are designed to target and reduce the faulty immune cells that attack the skin. The main goal is to check safety and find the right dose, with the hope of controlling the disease long-term.

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Conditions

The condition(s) this trial relates to.

autoimmune disease immune system disorder pemphigus pemphigus vulgaris vesiculobullous skin disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEMPHIGUS VULGARIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
MD Anderson Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
Mount Sinai - Icahn School of Medicine
WITHDRAWN

New York, New York, 10029, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Stanford University, Dept. of Dermatology
RECRUITING

Redwood City, California, 94063, United States
UC Davis, Dept. of Dermatology
RECRUITING

Sacramento, California, 95816, United States
UT Southwestern Medical Center, Dept. of Dermatology
RECRUITING

Dallas, Texas, 75235, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of North Carolina, Department of Dermatology
WITHDRAWN

Chapel Hill, North Carolina, 27516, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Washington
COMPLETED

Seattle, Washington, 98109, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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