Immunotherapy combo shows promise for rare, aggressive breast cancer

NCT ID NCT03515798

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 26 times

Summary

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before surgery can improve outcomes for people with HER2-negative inflammatory breast cancer, a rare and aggressive form of the disease. About 52 participants will receive either chemo alone or chemo plus pembrolizumab every 3 weeks. The main goal is to see if the combination leads to a higher rate of complete tumor disappearance by the time of surgery.

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Contacts and locations

Locations

  • CENTRE Francois Baclesse

    Caen, France

  • Centre Georges Francois Leclerc

    Dijon, 21079, France

  • Centre Henri Becquerel

    Rouen, France

  • Centre Leon Berard

    Lyon, France

  • Centre Paul Strauss

    Strasbourg, France

  • Clinique de L'Europe

    Amiens, France

  • IUCT-Oncopole Institut Claudius Rigaud

    Toulouse, France

  • Institut BERGONIE

    Bordeaux, France

  • Institut Curie

    Paris, France

  • Institut Curie hopital rene huguenin

    Saint-Cloud, France

  • Institut Sainte Catherine

    Avignon, France

  • Institut de cancérologie de la loire

    Saint-Priest-en-Jarez, France

Conditions

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