New pill hopes to shrink painful NF1 tumors without surgery
NCT ID NCT06961565
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 24 times
Summary
This early-stage study tests a daily pill called PAS-004 in adults with neurofibromatosis type 1 (NF1) who have at least one symptomatic, inoperable nerve tumor (plexiform neurofibroma). The main goals are to find safe doses and understand side effects. The study has two parts: Part A tests different doses, and Part B tests two selected doses for up to 6 months. About 56 participants will take the drug once daily and be monitored with blood tests and MRIs.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, 3000, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal North Shore Hospital
RECRUITINGSt Leonards, New South Wales, 2065, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Severance Hospital, Yonsei University Health System
RECRUITINGSinchŏn-dong, 6164, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Conditions
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