New cancer pill enters first human safety trial
NCT ID NCT06299839
First seen Dec 29, 2025 · Last updated Apr 16, 2026 · Updated 16 times
Summary
This is the first study in people testing an experimental pill called PAS-004 for advanced solid tumors that have specific genetic mutations (RAS, NF1, or RAF) or have stopped responding to standard treatments. The main goals are to find a safe dose, understand the side effects, and see how the body processes the drug. Up to 48 adults with advanced cancer who have run out of other treatment options will take the pill daily for up to two years while doctors closely monitor their health.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Institute of Oncology Bucharest Prof. Dr. Alexandru Trestioreanu
RECRUITINGBucharest, 022328, Romania
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute of Oncology Prof. Dr. Ion Chiricuta
RECRUITINGCluj-Napoca, RO-400015, Romania
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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MBAL Sveta Sofia
RECRUITINGSofia, 1404, Bulgaria
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Oncology
ACTIVE_NOT_RECRUITINGAustin, Texas, 78758, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGIrving, Texas, 75039, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGFairfax, Virginia, 22031, United States
Conditions
Explore the condition pages connected to this study.