New MEK inhibitor PAS-004 enters human trials for Hard-to-Treat cancers
NCT ID NCT06299839
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing a new drug called PAS-004 in people with advanced solid tumors that have certain gene mutations (RAS, NF1, or RAF). The main goal is to see how safe the drug is and what side effects it causes. About 48 participants will take the drug by mouth daily for up to 2 years, with regular check-ups to monitor their health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PAS-004 (a MEK inhibitor)
- What this could lead to
- If successful, this could lead to a new treatment option for people with advanced solid tumors that have specific genetic mutations.
- What could go wrong
- This is an early Phase 1 trial with only 48 participants, so it is primarily testing safety and dosing. The drug may not shrink tumors or may cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Institute of Oncology Bucharest Prof. Dr. Alexandru Trestioreanu
RECRUITINGBucharest, 022328, Romania
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Institute of Oncology Prof. Dr. Ion Chiricuta
RECRUITINGCluj-Napoca, RO-400015, Romania
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MBAL Sveta Sofia
RECRUITINGSofia, 1404, Bulgaria
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NEXT Oncology
ACTIVE_NOT_RECRUITINGAustin, Texas, 78758, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGIrving, Texas, 75039, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT Oncology
ACTIVE_NOT_RECRUITINGFairfax, Virginia, 22031, United States
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