New Valve-in-Valve procedure offers hope for failing heart valves

NCT ID NCT03193801

First seen Nov 05, 2025 · Last updated May 13, 2026 · Updated 24 times

Summary

This study tests a less invasive way to replace a failing mitral heart valve without open-heart surgery. About 53 people with a previously implanted surgical valve that is now leaking or narrowed will receive a new valve placed inside the old one. The goal is to see if this procedure is safe and helps the heart pump better, reducing symptoms like shortness of breath.

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Contacts and locations

Locations

  • Barnes-Jewish Hospital/ Washington University

    St Louis, Missouri, 63110, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Instituto Dante Pazzanese de Cardiologia

    Vila Mariana, São Paulo, 04012-909, Brazil

  • Instituto do Coração da Universidade de São Paulo

    Cerqueira César, São Paulo, 05403-900, Brazil

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • NYU Lagone Medical Center

    New York, New York, 10016, United States

  • Northshore University Health System Research Institution

    Evanston, Illinois, 60201, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Providence Heart & Vascular Institution

    Portland, Oregon, 97225, United States

  • The Heart Hospital of Baylor Plano

    Plano, Texas, 75093, United States

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

Conditions

Explore the condition pages connected to this study.