Can enzyme pills help after stomach surgery? new trial aims to find out

NCT ID NCT06058442

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether taking pancreatic enzyme capsules (NORTASE®) for six months can improve quality of life and prevent weight loss in people who have had most or all of their stomach removed. About 188 adults who had a gastrectomy will receive either the enzyme or a placebo. The main goal is to see if physical functioning improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

NORTASE® (pancreatic enzymes)

What this could lead to

If it works, this could offer a way to improve quality of life and prevent weight loss after stomach removal surgery.

What could go wrong

This is a phase 3 trial, but it is still relatively small (188 people) and tests a specific supplement. The benefits may be modest and not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Carl-Thiem-Klinikum Cottbus gGmbH; 4. Medizinische Klinik

    RECRUITING

    Cottbus, 03048, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Helios Kliniken Schwerin; Klinik für Allgemein- und Viszeralchirurgie

    RECRUITING

    Schwerin, 19055, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • KEM | Evang. Kliniken Essen-Mitte gGmbH, Klinik für Internistische Onkologie

    NOT_YET_RECRUITING

    Essen, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Ulm

    RECRUITING

    Ulm, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie Universitätsklinikum Leipzig

    RECRUITING

    Leipzig, 04103, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Klinikum St. Georg, Abteilung für Allgemein-, Viszeral- und Onkologische Chirurgie

    RECRUITING

    Leipzig, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sana Kliniken Leipziger Land GmbH, Klinik für Allgemein-, Viszeral-, MIC- und Gefäßchirurgie / Thoraxchirurgie

    NOT_YET_RECRUITING

    Borna, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UNIVERSITÄTSKLINIKUM FREIBURG Klinik für Allgemein- und Viszeralchirurgie Department Chirurgie

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Universitätsklinikum Jena, Allgemein-, Viszeral- und Gefäßchirurgie

    RECRUITING

    Jena, 07740, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••