New trial aims to cut opioid use in pancreatic cancer with early nerve block

NCT ID NCT06160323

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether giving a nerve block early, rather than waiting, can better control pain in people with inoperable pancreatic cancer. The procedure uses an endoscope to inject numbing medication near nerves that carry pain signals. Researchers will compare pain scores and opioid use between the early nerve block group and those who follow standard step-up pain management.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
EUS-guided celiac ganglion neurolysis (nerve block procedure)
What this could lead to
If it works, this could offer a more effective way to control severe pain in pancreatic cancer patients, reducing reliance on strong opioids and their side effects.
What could go wrong
This is a relatively small trial (94 people) and the procedure carries risks like bleeding or nerve damage. It may not prove better than standard care, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Prince of Wales Hospital

    RECRUITING

    Hong Kong, Hong Kong, 00000, Hong Kong

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