New hope for ovarian cancer: targeted drug combo enters Mid-Stage trial

NCT ID NCT07059845

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 10 times

Summary

This Phase 2 trial tests mirvetuximab soravtansine, a targeted drug, combined with standard chemotherapy (carboplatin) or bevacizumab in 400 people with a specific type of ovarian cancer (FRα-positive). The study aims to find the best dose and combination to shrink tumors and control the disease while monitoring side effects. Participants will receive intravenous infusions and be followed for about 40 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mirvetuximab soravtansine (a targeted drug) combined with carboplatin or bevacizumab
What this could lead to: If successful, this could lead to better treatment options for people with a specific type of ovarian cancer, potentially improving tumor shrinkage and delaying progression.
What could go wrong: This is a Phase 2 trial, so it's still early. The drug combinations may cause side effects like eye problems or other adverse events, and not all participants may benefit. Results may not apply to all ovarian cancer patients.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer malignant ovarian serous tumor ovarian cancer ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

AZ Maria Middelares /ID# 276325
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Aalborg University Hospital /ID# 276435
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Asan Medical Center /ID# 276955
RECRUITING

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Austin Hospital /ID# 276534
RECRUITING

Melbourne, Victoria, 3084, Australia
Avera Cancer Institute - Sioux Falls /ID# 278627
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Baptist Health Lexington /ID# 278267
RECRUITING

Lexington, Kentucky, 40503, United States
Barwon Health /ID# 277297
RECRUITING

Geelong, Victoria, 3220, Australia
Burnside War Memorial Hospital /ID# 277602
RECRUITING

Adelaide, South Australia, 5065, Australia
CHU de Liege /ID# 276500
RECRUITING

Liège, 4000, Belgium
CHU de Limoges site CHU Dupuytren 1 /ID# 276851
RECRUITING

Limoges, New Aquitaine, 87000, France
Centre Antoine-Lacassagne /ID# 276708
RECRUITING

Nice, Provence-Alpes-Côte d'Azur Region, 06189, France
Centre Francois Baclesse /ID# 276709
RECRUITING

Caen, Calvados, 14076, France
Centre Georges Francois Leclerc /ID# 276737
RECRUITING

Dijon, Bourgogne-Franche-Comté, 21079, France
Centre Leon Berard /ID# 276710
RECRUITING

Lyon, Rhone, 69373, France
Chris O'Brien Lifehouse /ID# 276337
RECRUITING

Sydney, New South Wales, 2050, Australia
Clinica Universidad de Navarra - Madrid /ID# 276411
RECRUITING

Madrid, 28027, Spain
Cliniques Universitaires UCL Saint-Luc /ID# 276321
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Complejo Hospitalario Universitario A Coruna /ID# 276416
RECRUITING

A Coruña, 15006, Spain
Complejo Hospitalario Universitario Insular-Materno Infantil de Gran Canaria /ID# 276438
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
Epworth Hospital - Richmond /ID# 276347
RECRUITING

Richmond, Victoria, 3121, Australia
Fakultni nemocnice Hradec Kralove - Sokolska /ID# 276205
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Motol a Homolka /ID# 276300
RECRUITING

Prague, Praha 5, 150 06, Czechia
FirstHealth of the Carolinas- Speciality Center /ID# 278636
RECRUITING

Pinehurst, North Carolina, 28374, United States
Florida Cancer Specialists - East /ID# 278605
RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists - North /ID# 278626
RECRUITING

St. Petersburg, Florida, 33705, United States
Herlev Hospital /ID# 276831
RECRUITING

Herlev, Capital Region, 2730, Denmark
Hopital Prive Des Cotes D'Armor /ID# 276706
RECRUITING

Plérin, Cotes-d Armor, 22190, France
Hospital Clinic de Barcelona /ID# 276412
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos. /ID# 276407
RECRUITING

Madrid, 28040, Spain
Hospital Clinico Universitario Lozano Blesa /ID# 276406
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitari Vall d Hebron /ID# 276478
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Donostia /ID# 276404
RECRUITING

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
Hospital Universitario Marques de Valdecilla /ID# 276415
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 281304
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen del Rocio /ID# 276426
RECRUITING

Seville, Sevilla, 41013, Spain
IUCT Oncopole /ID# 276705
RECRUITING

Toulouse, Occitanie, 31059, France
Icon Cancer Centre Hobart /ID# 277688
RECRUITING

Hobart, Tasmania, 7000, Australia
Icon Cancer Centre Wesley /ID# 277199
RECRUITING

Auchenflower, Queensland, 4066, Australia
Institut Bergonie /ID# 276696
RECRUITING

Bordeaux, Gironde, 33076, France
Institut Catala D Oncologia - Ico - Girona /ID# 276410
RECRUITING

Girona, 17007, Spain
Institut Curie -Site Saint-Cloud /ID# 276850
RECRUITING

Saint-Cloud, Hauts-de-Seine, 92210, France
Institut Godinot /ID# 276849
RECRUITING

Reims, Marne, 51726, France
Institut Gustave Roussy /ID# 276712
RECRUITING

Villejuif, Île-de-France Region, 94800, France
Institut du Cancer Avignon Provence - Sainte Catherine /ID# 276692
RECRUITING

Avignon, Vaucluse, 84918, France
Instituto Valenciano de Oncologia /ID# 276413
RECRUITING

Valencia, 46009, Spain
Intermountain Health - Intermountain Health West End Clinic /ID# 278470
RECRUITING

Billings, Montana, 59106, United States
Jamescare Gynecologic Oncology At Mill Run /ID# 277951
RECRUITING

Hilliard, Ohio, 43026, United States
Karmanos Cancer Institute - Detroit /ID# 277085
RECRUITING

Detroit, Michigan, 48201, United States
Korea University Guro Hospital /ID# 276194
RECRUITING

Seoul, Seoul Teugbyeolsi, 08308, South Korea
Maine Medical Center - Scarborough Campus /ID# 277205
RECRUITING

Scarborough, Maine, 04074, United States
Masarykuv Onkologicky Ustav /ID# 276080
RECRUITING

Brno, Brno-mesto, 656 53, Czechia
Md Anderson Cancer Center At Cooper /ID# 278390
RECRUITING

Camden, New Jersey, 08103, United States
Monash Health - Monash Medical Centre - Clayton /ID# 276984
RECRUITING

Clayton, Victoria, 3168, Australia
National Cancer Center /ID# 276283
RECRUITING

Goyang-si, Gyeonggido, 10408, South Korea
Odense University Hospital /ID# 276462
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Orlando Health Cancer Institute Gynecologic Cancer Center - Orlando /ID# 278623
RECRUITING

Orlando, Florida, 32806, United States
Our Lady of the Lake Physician Group - Medical Oncology /ID# 277440
RECRUITING

Baton Rouge, Louisiana, 70817, United States
Penn Medicine University of Pennsylvania Health System /ID# 277963
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
SUNY Upstate Medical University - Syracuse /ID# 277245
RECRUITING

Syracuse, New York, 13210, United States
Samsung Medical Center /ID# 276261
RECRUITING

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Sansum Clinic - Solvang /ID# 277712
ACTIVE_NOT_RECRUITING

Solvang, California, 93463, United States
Seoul National University Bundang Hospital /ID# 276280
RECRUITING

Seongnam-si, Gyeonggido, 13620, South Korea
Seoul National University Hospital /ID# 276182
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
St. George Private Hospital /ID# 276570
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. John Of God Subiaco Hospital /ID# 277174
RECRUITING

Subiaco, Western Australia, 6008, Australia
Strasbourg Oncologie Liberale /ID# 276698
RECRUITING

Strasbourg, Bas-Rhin, 67000, France
Texas Oncology - Abilene - Antilley Road /ID# 277739
RECRUITING

Abilene, Texas, 79606, United States
Texas Oncology - Fort Worth Cancer Center /ID# 277989
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology - Northeast Texas /ID# 277737
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 277735
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology - The Woodlands /ID# 277926
RECRUITING

The Woodlands, Texas, 77380, United States
UC San Diego Health - Moores Cancer Center /ID# 277574
RECRUITING

La Jolla, California, 92037, United States
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 277183
RECRUITING

Namur, 5000, Belgium
Universitair Ziekenhuis Leuven /ID# 276316
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
University Of Tennessee Medical Center /ID# 278225
RECRUITING

Knoxville, Tennessee, 37920, United States
University of Florida College of Medicine /ID# 278348
RECRUITING

Gainesville, Florida, 32610, United States
Virginia Mason Hospital and Medical Center /ID# 277259
RECRUITING

Seattle, Washington, 98101, United States
Vseobecna Fakultni nemocnice v Praze /ID# 276213
RECRUITING

Prague, Praha 17, 128 00, Czechia
West Virginia University Hospitals /ID# 278965
RECRUITING

Morgantown, West Virginia, 26506, United States
Western Pennsylvania Gynecologic Oncology /ID# 278632
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Willamette Valley Cancer Institute and Research Center /ID# 277714
RECRUITING

Eugene, Oregon, 97401, United States
Yonsei University Health System Severance Hospital /ID# 276266
RECRUITING

Seoul, Seoul Teugbyeolsi, 03722, South Korea

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