New drug combo before surgery shows promise for lung cancer patients

NCT ID NCT04351555

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether giving the targeted drug osimertinib (Tagrisso) before surgery, alone or with chemotherapy, works better than standard chemotherapy alone for people with a specific type of lung cancer (EGFR-mutant, non-small cell). About 358 patients with stage II to IIIB disease will receive treatment before their tumor is removed. The main goal is to see if the tumor shrinks enough to leave few or no cancer cells behind.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Osimertinib (Tagrisso) with or without chemotherapy (cisplatin, carboplatin, pemetrexed)

What this could lead to

If successful, this could offer a more effective pre-surgery treatment for EGFR-mutant lung cancer, potentially improving survival and reducing recurrence.

What could go wrong

This is still a phase 3 trial, so results are not yet proven. Osimertinib can cause side effects like rash, diarrhea, and lung inflammation, and adding chemotherapy increases toxicity.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL-CELL LUNG CANCER

Contacts and locations

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Locations

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Duarte, California, 91010, United States
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Irvine, California, 92618, United States
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San Francisco, California, 94143, United States
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Santa Monica, California, 90404, United States
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Santa Rosa, California, 95403, United States
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Boston, Massachusetts, 02215, United States
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Lebanon, New Hampshire, 03756, United States
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Commack, New York, 11725, United States
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New York, New York, 10032, United States
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Houston, Texas, 77030, United States
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Fairfax, Virginia, 22031, United States
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Seattle, Washington, 98104, United States
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Graz, 8036, Austria
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Vienna, 1210, Austria
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Barretos, 14784-400, Brazil
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Fortaleza, 60135-040, Brazil
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Jaú, 17204310, Brazil
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Porto Alegre, 90035-000, Brazil
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Porto Alegre, 90610-000, Brazil
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Recife, 52010-075, Brazil
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Rio de Janeiro, 22271-110, Brazil
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Santa Maria, 97015-450, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 04038-034, Brazil
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São Paulo, 04501-000, Brazil
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Panagyurishte, 4500, Bulgaria
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Pleven, 5804, Bulgaria
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Sofia, 1113, Bulgaria
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Toronto, Ontario, M5G 2N2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Las Condes, 7560908, Chile
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Santiago, 7500713, Chile
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Santiago, 7500921, Chile
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Beijing, 100142, China
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Beijing, 100191, China
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Beijing, CN-100730, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400037, China
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Guangzhou, 510062, China
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Guangzhou, 510095, China
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Guangzhou, 510120, China
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Guangzhou, 510515, China
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Hangzhou, 310009, China
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Hangzhou, 310022, China
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Kunming, 650118, China
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Nanchang, 330006, China
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Nantong, 226001, China
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Shandong, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200433, China
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Suzhou, 215006, China
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Ürümqi, 830000, China
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Wanzhou, 404000, China
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Wenzhou, CN-325000, China
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Xiamen, 361004, China
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Yangzhou, 225001, China
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Avignon, 84902, France
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Bordeaux, 33000, France
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Berlin, 12351, Germany
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Bielefeld, 33611, Germany
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Cologne, 51109, Germany
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Esslingen a.N., 73730, Germany
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Freiburg im Breisgau, 79106, Germany
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Gauting, 82131, Germany
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Georgsmarienhütte, 49124, Germany
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Halle, 06120, Germany
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Oldenburg, 26121, Germany
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Würzburg, 97067, Germany
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Mumbai, 400012, India
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Namakkal, 637001, India
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New Delhi, 110029, India
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Varanasi, 221005, India
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 95847, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 5265601, Israel
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Tel Aviv, 62748, Israel
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Bari, 70124, Italy
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Florence, 50134, Italy
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Monza, 20900, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Rozzano, 20089, Italy
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Varese, 21100, Italy
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Akashi-shi, 673-8558, Japan
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Bunkyō City, 113-8431, Japan
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Chiba, 260-8677, Japan
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Hiroshima, 734-8551, Japan
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Kashiwa, 227-8577, Japan
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Kōtoku, 135-8550, Japan
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Kyoto, 606-8507, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakai, 590-0197, Japan
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Sakaishi, 591-8555, Japan
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Sendai, 981-0914, Japan
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Shinjuku-ku, 160-0023, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 241-8515, Japan
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Aguascalientes, 20230, Mexico
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D.F, 14050, Mexico
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Mexico City, '14080, Mexico
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La Libertad, 13013, Peru
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Lima, 0051, Peru
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Lima, 15036, Peru
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Lima, L41, Peru
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Lima, LIMA 34, Peru
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Olsztyn, 10-357, Poland
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Kazan', 420029, Russia
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Krasnoyarsk, 660133, Russia
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Moscow, 105229, Russia
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Nizhny Novgorod, 603081, Russia
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Obninsk, 249036, Russia
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Perm, 614990, Russia
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Saint Petersburg, 191036, Russia
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Saint Petersburg, 197758, Russia
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Daegu, 41404, South Korea
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Hwasun-gun, 58128, South Korea
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Incheon, 21431, South Korea
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Seoul, 02447, South Korea
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Seoul, 08308, South Korea
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Seoul, 42601, South Korea
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Yangsan, 50612, South Korea
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Barcelona, 08035, Spain
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Madrid, 28040, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Winterthur, 8401, Switzerland
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Zurich, CH-8091, Switzerland
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Taichung, 40201, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taipei, 112, Taiwan
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Taipei, 235, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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Pathum Thani, 12120, Thailand
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Phisanulok, 65000, Thailand
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Ankara, 6500, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Istanbul, 34214, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Liverpool, L7 8YA, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam