New combo therapy aims to reopen collapsed lungs in ventilator patients

NCT ID NCT07451405

Recruiting now Disease control Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new therapy called oscillation and lung expansion (OLE) in 60 adults on ventilators who have collapsed lungs (atelectasis). OLE combines continuous pressure, high-frequency vibrations, and medication mist to clear mucus and reopen lung tissue. Researchers will compare it to standard chest wall vibration therapy using CT scans and electrical impedance tomography to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oscillation and lung expansion (OLE) therapy
What this could lead to: If successful, this could provide a more effective and comfortable way to treat lung collapse in patients on ventilators, potentially reducing complications.
What could go wrong: This is a small, early-stage trial with only 60 participants, so results may not apply to all patients. The therapy may not work better than current methods and could cause discomfort or injury.

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Conditions

The condition(s) this trial relates to.

middle lobe syndrome Pulmonary Atelectasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATELECTASIS

Contacts and locations

Locations

Respiratory rehabilitation center
RECRUITING

Beijing, Beijing Municipality, 100144, China
Shuo Chen
COMPLETED

Beijing, China

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