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Can skipping opioids during anesthesia prevent Post-Surgery nausea?

NCT ID NCT07806162

Symptom relief Sponsor: Sohag University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether using an opioid-free anesthesia method can lower the chance of nausea and vomiting in the first day after lung surgery. Adults scheduled for a thoracoscopic lung resection will receive either the opioid-free approach or standard opioid-based anesthesia. Researchers will compare how often nausea and vomiting occur, as well as pain levels and recovery quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioid-free anesthesia using a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol, compared with standard opioid-based anesthesia using fentanyl and sevoflurane.
What this could lead to
If opioid-free anesthesia works, it could offer a way to reduce postoperative nausea and vomiting, improving recovery and comfort after lung surgery.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. The opioid-free approach might not reduce nausea as hoped, and could have other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:- * Eligible participants were adults (18-80 years). * Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia Exclusion Criteria: * Contraindication to any study drug (e.g., heart block, severe liver disease, allergy). * Chronic opioid use (\>30 MME/day for \>3 months). * Patients with renal impairment (e GFR \<30 mL/min). * Pregnancy. * Inability to comprehend pain scales.

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PONV

How to take part

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  1. The official record

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